CNPY3 [The Human Chemical-Genetic Interaction Map Project]

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======= CNPY3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNPY3
  * **<color #00a2e8>Official Name</color>**: canopy FGF signaling regulator 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10695|10695]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BT09|Q9BT09]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNPY3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNPY3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610774|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3456|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|toll-like receptor signaling pathway|
|pattern recognition receptor signaling pathway|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|endoplasmic reticulum lumen|
|signaling receptor binding|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|regulation of innate immune response|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|positive regulation of immune response|
|defense response to other organism|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|regulation of immune system process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.88|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.7|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.71|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.72|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.74|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.82|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.47|
|[[:human genes:a:aqr|AQR]]|0.444|
|[[:human genes:c:cope|COPE]]|0.444|
|[[:human genes:o:orc1|ORC1]]|0.437|
|[[:human genes:m:myo1h|MYO1H]]|0.435|
|[[:human genes:i:iscu|ISCU]]|0.433|
|[[:human genes:m:mt1e|MT1E]]|0.427|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.422|
|[[:human genes:t:tfip11|TFIP11]]|0.42|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.417|
|[[:human genes:r:rps28|RPS28]]|0.415|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.413|
|[[:human genes:f:fut11|FUT11]]|0.412|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.411|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.41|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.41|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.41|
|[[:human genes:c:c14orf93|C14orf93]]|0.405|
|[[:human genes:k:kctd17|KCTD17]]|0.405|
|[[:human genes:c:cmya5|CMYA5]]|0.402|
|[[:human genes:s:syt9|SYT9]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2440
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNPY3 Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>