COA3 [The Human Chemical-Genetic Interaction Map Project]

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======= COA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COA3
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase assembly factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28958|28958]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2R0|Q9Y2R0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614775|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function. [provided by RefSeq, Nov 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. {ECO:0000269|PubMed:23260140}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Coiled-coil 56|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex IV|
|positive regulation of mitochondrial translation|
|mitochondrial respiratory chain complex IV assembly|
|respiratory chain complex IV assembly|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|cytochrome complex assembly|
|integral component of mitochondrial inner membrane|
|mitochondrial respiratory chain complex assembly|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|regulation of translation|
|regulation of cellular amide metabolic process|
|mitochondrion organization|
|posttranscriptional regulation of gene expression|
|cellular protein-containing complex assembly|
|mitochondrion|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.17|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.74|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.71|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.7|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.72|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.82|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.84|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.85|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.86|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.88|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.89|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.06|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.08|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.09|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.67|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.724|
|[[:human genes:p:pet117|PET117]]|0.724|
|[[:human genes:n:nars2|NARS2]]|0.695|
|[[:human genes:q:qrsl1|QRSL1]]|0.68|
|[[:human genes:e:ears2|EARS2]]|0.68|
|[[:human genes:s:sco2|SCO2]]|0.679|
|[[:human genes:c:cox11|COX11]]|0.671|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.661|
|[[:human genes:c:coa6|COA6]]|0.646|
|[[:human genes:f:fastkd5|FASTKD5]]|0.645|
|[[:human genes:m:mrps16|MRPS16]]|0.643|
|[[:human genes:d:dars2|DARS2]]|0.641|
|[[:human genes:y:yars2|YARS2]]|0.639|
|[[:human genes:p:pet112|PET112]]|0.639|
|[[:human genes:m:mrps21|MRPS21]]|0.635|
|[[:human genes:m:mrps6|MRPS6]]|0.632|
|[[:human genes:d:dap3|DAP3]]|0.628|
|[[:human genes:v:vars2|VARS2]]|0.623|
|[[:human genes:t:tars2|TARS2]]|0.616|
|[[:human genes:a:aars2|AARS2]]|0.615|
|[[:human genes:m:mrpl23|MRPL23]]|0.61|
|[[:human genes:f:ftsj2|FTSJ2]]|0.605|
|[[:human genes:m:mars2|MARS2]]|0.602|
|[[:human genes:m:malsu1|MALSU1]]|0.595|
|[[:human genes:r:rpusd4|RPUSD4]]|0.594|
|[[:human genes:c:cox16|COX16]]|0.594|
|[[:human genes:m:mrps34|MRPS34]]|0.593|
|[[:human genes:r:rars2|RARS2]]|0.593|
|[[:human genes:p:pars2|PARS2]]|0.592|
|[[:human genes:f:fars2|FARS2]]|0.59|
|[[:human genes:m:mrpl21|MRPL21]]|0.59|
|[[:human genes:m:mrps14|MRPS14]]|0.587|
|[[:human genes:m:mrps27|MRPS27]]|0.585|
|[[:human genes:g:gfm1|GFM1]]|0.583|
|[[:human genes:m:mrps5|MRPS5]]|0.581|
|[[:human genes:l:lars2|LARS2]]|0.58|
|[[:human genes:m:mrps26|MRPS26]]|0.58|
|[[:human genes:m:mrpl47|MRPL47]]|0.579|
|[[:human genes:m:mrps25|MRPS25]]|0.578|
|[[:human genes:r:rbfa|RBFA]]|0.572|
|[[:human genes:b:bcs1l|BCS1L]]|0.569|
|[[:human genes:c:cox15|COX15]]|0.567|
|[[:human genes:m:mettl17|METTL17]]|0.567|
|[[:human genes:h:hars2|HARS2]]|0.559|
|[[:human genes:p:polg|POLG]]|0.559|
|[[:human genes:m:mrpl49|MRPL49]]|0.559|
|[[:human genes:m:mrps2|MRPS2]]|0.557|
|[[:human genes:m:mrps12|MRPS12]]|0.556|
|[[:human genes:c:cox7b|COX7B]]|0.554|
|[[:human genes:m:mrpl45|MRPL45]]|0.552|
|[[:human genes:m:mrpl3|MRPL3]]|0.551|
|[[:human genes:m:mrps18a|MRPS18A]]|0.549|
|[[:human genes:m:mtg2|MTG2]]|0.547|
|[[:human genes:s:sars2|SARS2]]|0.545|
|[[:human genes:m:mrpl53|MRPL53]]|0.544|
|[[:human genes:m:mrpl18|MRPL18]]|0.544|
|[[:human genes:n:ndufb11|NDUFB11]]|0.544|
|[[:human genes:c:cars2|CARS2]]|0.544|
|[[:human genes:d:ddx28|DDX28]]|0.544|
|[[:human genes:m:mrps35|MRPS35]]|0.54|
|[[:human genes:c:coa5|COA5]]|0.539|
|[[:human genes:w:wars2|WARS2]]|0.537|
|[[:human genes:t:tfb1m|TFB1M]]|0.534|
|[[:human genes:c:cox17|COX17]]|0.534|
|[[:human genes:m:mrps22|MRPS22]]|0.528|
|[[:human genes:g:gfm2|GFM2]]|0.528|
|[[:human genes:m:mrpl11|MRPL11]]|0.524|
|[[:human genes:p:polg2|POLG2]]|0.524|
|[[:human genes:m:mrps24|MRPS24]]|0.523|
|[[:human genes:p:ptcd3|PTCD3]]|0.522|
|[[:human genes:c:c12orf65|C12orf65]]|0.521|
|[[:human genes:m:mrpl43|MRPL43]]|0.52|
|[[:human genes:m:mterfd1|MTERFD1]]|0.516|
|[[:human genes:m:mrpl17|MRPL17]]|0.515|
|[[:human genes:m:mrp63|MRP63]]|0.515|
|[[:human genes:w:wbscr16|WBSCR16]]|0.513|
|[[:human genes:m:mrpl15|MRPL15]]|0.51|
|[[:human genes:c:cox6b1|COX6B1]]|0.509|
|[[:human genes:a:aifm1|AIFM1]]|0.505|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.504|
|[[:human genes:c:c10orf2|C10orf2]]|0.503|
|[[:human genes:m:mtg1|MTG1]]|0.5|
|[[:human genes:m:mtpap|MTPAP]]|0.499|
|[[:human genes:p:polrmt|POLRMT]]|0.498|
|[[:human genes:m:mrpl12|MRPL12]]|0.497|
|[[:human genes:l:lrpprc|LRPPRC]]|0.497|
|[[:human genes:r:rpusd3|RPUSD3]]|0.496|
|[[:human genes:n:ndufa2|NDUFA2]]|0.493|
|[[:human genes:t:tomm20|TOMM20]]|0.493|
|[[:human genes:m:mrpl44|MRPL44]]|0.493|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.492|
|[[:human genes:t:trub2|TRUB2]]|0.491|
|[[:human genes:p:pgm3|PGM3]]|0.491|
|[[:human genes:m:mipep|MIPEP]]|0.489|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.488|
|[[:human genes:m:mrps10|MRPS10]]|0.487|
|[[:human genes:m:mrpl4|MRPL4]]|0.487|
|[[:human genes:n:ndufa3|NDUFA3]]|0.487|
|[[:human genes:m:mrpl35|MRPL35]]|0.482|
|[[:human genes:h:higd2a|HIGD2A]]|0.481|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.48|
|[[:human genes:m:mcat|MCAT]]|0.48|
|[[:human genes:n:nsun4|NSUN4]]|0.477|
|[[:human genes:c:coq2|COQ2]]|0.477|
|[[:human genes:m:mrpl22|MRPL22]]|0.474|
|[[:human genes:c:chchd1|CHCHD1]]|0.472|
|[[:human genes:m:mterfd2|MTERFD2]]|0.472|
|[[:human genes:s:sco1|SCO1]]|0.471|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.47|
|[[:human genes:m:mrpl20|MRPL20]]|0.468|
|[[:human genes:m:mrpl1|MRPL1]]|0.465|
|[[:human genes:e:eral1|ERAL1]]|0.464|
|[[:human genes:m:mrpl33|MRPL33]]|0.462|
|[[:human genes:a:acad9|ACAD9]]|0.462|
|[[:human genes:m:mrpl2|MRPL2]]|0.462|
|[[:human genes:g:gatc|GATC]]|0.459|
|[[:human genes:a:atp5c1|ATP5C1]]|0.457|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.455|
|[[:human genes:m:mrps9|MRPS9]]|0.452|
|[[:human genes:c:cox20|COX20]]|0.452|
|[[:human genes:c:clpp|CLPP]]|0.452|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.451|
|[[:human genes:f:fastkd2|FASTKD2]]|0.451|
|[[:human genes:m:mrpl55|MRPL55]]|0.45|
|[[:human genes:n:ndufs2|NDUFS2]]|0.45|
|[[:human genes:s:slc31a1|SLC31A1]]|0.45|
|[[:human genes:f:fastkd1|FASTKD1]]|0.449|
|[[:human genes:m:mrps7|MRPS7]]|0.447|
|[[:human genes:i:iba57|IBA57]]|0.447|
|[[:human genes:m:mrpl37|MRPL37]]|0.445|
|[[:human genes:m:mrpl42|MRPL42]]|0.445|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.444|
|[[:human genes:m:mrpl39|MRPL39]]|0.442|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.442|
|[[:human genes:m:mrpl34|MRPL34]]|0.441|
|[[:human genes:m:mrpl52|MRPL52]]|0.438|
|[[:human genes:n:ndufc2|NDUFC2]]|0.437|
|[[:human genes:s:ssbp1|SSBP1]]|0.437|
|[[:human genes:n:ndufv1|NDUFV1]]|0.437|
|[[:human genes:c:cox19|COX19]]|0.437|
|[[:human genes:n:ndufa1|NDUFA1]]|0.435|
|[[:human genes:t:tufm|TUFM]]|0.435|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.434|
|[[:human genes:t:tefm|TEFM]]|0.434|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.433|
|[[:human genes:m:mto1|MTO1]]|0.431|
|[[:human genes:m:mrpl51|MRPL51]]|0.431|
|[[:human genes:m:mrps18b|MRPS18B]]|0.431|
|[[:human genes:p:ptcd1|PTCD1]]|0.429|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.429|
|[[:human genes:t:tmem242|TMEM242]]|0.427|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.425|
|[[:human genes:n:nubpl|NUBPL]]|0.425|
|[[:human genes:n:ndufb6|NDUFB6]]|0.423|
|[[:human genes:m:mrpl32|MRPL32]]|0.423|
|[[:human genes:m:mrpl28|MRPL28]]|0.423|
|[[:human genes:m:mtif2|MTIF2]]|0.421|
|[[:human genes:c:cox6c|COX6C]]|0.421|
|[[:human genes:g:grsf1|GRSF1]]|0.418|
|[[:human genes:p:pdss1|PDSS1]]|0.417|
|[[:human genes:m:mrpl9|MRPL9]]|0.416|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.416|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.416|
|[[:human genes:m:mrps28|MRPS28]]|0.413|
|[[:human genes:m:mrpl10|MRPL10]]|0.413|
|[[:human genes:p:pnpt1|PNPT1]]|0.412|
|[[:human genes:m:mrps23|MRPS23]]|0.41|
|[[:human genes:p:pet100|PET100]]|0.409|
|[[:human genes:s:slc25a26|SLC25A26]]|0.408|
|[[:human genes:e:ecsit|ECSIT]]|0.407|
|[[:human genes:t:tmem261|TMEM261]]|0.406|
|[[:human genes:c:cox4i1|COX4I1]]|0.403|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.402|
|[[:human genes:c:coq4|COQ4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 185
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COA3 Expression in NALM6 Cells: 2.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>