COBL [The Human Chemical-Genetic Interaction Map Project]

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======= COBL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COBL
  * **<color #00a2e8>Official Name</color>**: cordon-bleu WH2 repeat protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23242|23242]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75128|O75128]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COBL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COBL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610317|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cobl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|collateral sprouting in absence of injury|
|somite specification|
|floor plate development|
|actin filament network formation|
|dendritic growth cone|
|collateral sprouting|
|positive regulation of ruffle assembly|
|segment specification|
|notochord development|
|actin monomer binding|
|axonal growth cone|
|regulation of ruffle assembly|
|actin filament polymerization|
|embryonic axis specification|
|actin polymerization or depolymerization|
|embryonic pattern specification|
|somitogenesis|
|positive regulation of dendrite development|
|actin filament|
|somite development|
|axis specification|
|protein polymerization|
|developmental cell growth|
|cell growth|
|neural tube closure|
|tube closure|
|ruffle|
|segmentation|
|primary neural tube formation|
|positive regulation of plasma membrane bounded cell projection assembly|
|neural tube formation|
|developmental growth involved in morphogenesis|
|embryonic epithelial tube formation|
|liver development|
|hepaticobiliary system development|
|digestive tract development|
|epithelial tube formation|
|cell cortex|
|digestive system development|
|morphogenesis of embryonic epithelium|
|tube formation|
|regulation of dendrite development|
|neural tube development|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|anterior/posterior pattern specification|
|actin filament organization|
|positive regulation of neuron projection development|
|axon|
|epithelial tube morphogenesis|
|regionalization|
|positive regulation of neuron differentiation|
|neuronal cell body|
|axonogenesis|
|positive regulation of cell projection organization|
|developmental growth|
|growth|
|axon development|
|gland development|
|dendrite|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|pattern specification process|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of cell projection organization|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|tube development|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|embryo development|
|neuron differentiation|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.84|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.95|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.96|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.2|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12551
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COBL Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>