COG7 [The Human Chemical-Genetic Interaction Map Project]

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======= COG7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COG7
  * **<color #00a2e8>Official Name</color>**: component of oligomeric golgi complex 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91949|91949]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P83436|P83436]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COG7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COG7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606978|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal Golgi function. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COG7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi transport complex|
|protein localization to Golgi apparatus|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|trans-Golgi network membrane|
|Golgi organization|
|protein stabilization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|regulation of protein stability|
|glycoprotein biosynthetic process|
|Golgi vesicle transport|
|glycoprotein metabolic process|
|endomembrane system organization|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|protein localization to organelle|
|nucleolus|
|Golgi apparatus|
|intracellular protein transport|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-3.66|
|[[:results:exp169|BH1 1μM R04 exp169]]|-3.08|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-3.06|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-3.02|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.74|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.64|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.49|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.4|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.38|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.3|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.29|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.23|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.21|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-2.19|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.12|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-2.11|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.99|
|[[:results:exp539|42°C R08 exp539]]|-1.94|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.91|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.88|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.87|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.86|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.85|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.82|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.78|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.72|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.72|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.71|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:unc50|UNC50]]|0.637|
|[[:human genes:c:cog5|COG5]]|0.611|
|[[:human genes:c:cog6|COG6]]|0.584|
|[[:human genes:g:gpr107|GPR107]]|0.555|
|[[:human genes:r:rab1b|RAB1B]]|0.514|
|[[:human genes:s:scyl1|SCYL1]]|0.5|
|[[:human genes:a:arl1|ARL1]]|0.489|
|[[:human genes:z:zfat|ZFAT]]|0.469|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.461|
|[[:human genes:s:scap|SCAP]]|0.458|
|[[:human genes:w:wdr7|WDR7]]|0.456|
|[[:human genes:m:mbtps1|MBTPS1]]|0.45|
|[[:human genes:c:cog8|COG8]]|0.445|
|[[:human genes:c:cog4|COG4]]|0.44|
|[[:human genes:c:c10orf76|C10orf76]]|0.44|
|[[:human genes:c:cog3|COG3]]|0.439|
|[[:human genes:c:cog2|COG2]]|0.439|
|[[:human genes:m:mtmr9|MTMR9]]|0.431|
|[[:human genes:p:pi4kb|PI4KB]]|0.43|
|[[:human genes:c:chka|CHKA]]|0.429|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.427|
|[[:human genes:g:get4|GET4]]|0.423|
|[[:human genes:c:cog1|COG1]]|0.418|
|[[:human genes:s:sptlc1|SPTLC1]]|0.415|
|[[:human genes:m:mtmr6|MTMR6]]|0.414|
|[[:human genes:t:trappc13|TRAPPC13]]|0.407|
|[[:human genes:d:dmxl1|DMXL1]]|0.404|
|[[:human genes:s:sgms1|SGMS1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|2/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|3/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4168
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COG7 Expression in NALM6 Cells: 4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>