COL16A1 [The Human Chemical-Genetic Interaction Map Project]

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======= COL16A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COL16A1
  * **<color #00a2e8>Official Name</color>**: collagen type XVI alpha 1 chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1307|1307]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07092|Q07092]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COL16A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COL16A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120326|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology. {ECO:0000269|PubMed:16754661}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|collagen type XVI trimer|
|integrin activation|
|cell adhesion mediated by integrin|
|positive regulation of focal adhesion assembly|
|positive regulation of adherens junction organization|
|positive regulation of cell junction assembly|
|extracellular matrix structural constituent conferring tensile strength|
|positive regulation of cell-matrix adhesion|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|regulation of adherens junction organization|
|cellular response to amino acid stimulus|
|regulation of cell junction assembly|
|integrin-mediated signaling pathway|
|response to amino acid|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|integrin binding|
|extracellular matrix structural constituent|
|female pregnancy|
|cellular response to acid chemical|
|multi-multicellular organism process|
|regulation of cell-substrate adhesion|
|extracellular matrix|
|endoplasmic reticulum lumen|
|extracellular matrix organization|
|response to acid chemical|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|positive regulation of cell adhesion|
|positive regulation of cellular component biogenesis|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|regulation of cell adhesion|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|multi-organism reproductive process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|extracellular space|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-2.49|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5486
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COL16A1 Expression in NALM6 Cells: -0.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>