COMMD3 [The Human Chemical-Genetic Interaction Map Project]

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======= COMMD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COMMD3
  * **<color #00a2e8>Official Name</color>**: COMM domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23412|23412]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBI1|Q9UBI1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COMMD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COMMD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616700|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:23637203, ECO:0000305|PubMed:21778237}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HCaRG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ficolin-1-rich granule lumen|
|sodium ion transport|
|monovalent inorganic cation transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|metal ion transport|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|cation transport|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|ion transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.72|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.54|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.16|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.1|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.08|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.7|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.79|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.87|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:commd5|COMMD5]]|0.613|
|[[:human genes:v:vps29|VPS29]]|0.605|
|[[:human genes:a:arpc4|ARPC4]]|0.588|
|[[:human genes:c:ccdc22|CCDC22]]|0.588|
|[[:human genes:a:actr3|ACTR3]]|0.581|
|[[:human genes:a:arpc2|ARPC2]]|0.565|
|[[:human genes:c:commd10|COMMD10]]|0.513|
|[[:human genes:c:commd2|COMMD2]]|0.51|
|[[:human genes:r:rab7a|RAB7A]]|0.499|
|[[:human genes:a:actr2|ACTR2]]|0.49|
|[[:human genes:c:commd9|COMMD9]]|0.489|
|[[:human genes:k:kiaa0196|KIAA0196]]|0.48|
|[[:human genes:c:commd7|COMMD7]]|0.478|
|[[:human genes:v:vps35|VPS35]]|0.455|
|[[:human genes:c:ccdc53|CCDC53]]|0.451|
|[[:human genes:g:gpr107|GPR107]]|0.446|
|[[:human genes:k:kiaa1033|KIAA1033]]|0.413|
|[[:human genes:c:commd4|COMMD4]]|0.412|
|[[:human genes:c:ccdc93|CCDC93]]|0.408|
|[[:human genes:c:c16orf62|C16orf62]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6963
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COMMD3 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>