COMMD7 [The Human Chemical-Genetic Interaction Map Project]

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======= COMMD7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COMMD7
  * **<color #00a2e8>Official Name</color>**: COMM domain containing 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=149951|149951]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VX2|Q86VX2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COMMD7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COMMD7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616703|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HCaRG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NF-kappaB binding|
|negative regulation of NF-kappaB transcription factor activity|
|tumor necrosis factor-mediated signaling pathway|
|negative regulation of DNA-binding transcription factor activity|
|cellular response to tumor necrosis factor|
|cytoplasmic vesicle|
|response to tumor necrosis factor|
|regulation of DNA-binding transcription factor activity|
|cytokine-mediated signaling pathway|
|intracellular membrane-bounded organelle|
|cellular response to cytokine stimulus|
|response to cytokine|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.64|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.1|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.73|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arpc2|ARPC2]]|0.595|
|[[:human genes:a:arpc4|ARPC4]]|0.565|
|[[:human genes:a:actr3|ACTR3]]|0.549|
|[[:human genes:c:commd5|COMMD5]]|0.544|
|[[:human genes:c:commd2|COMMD2]]|0.515|
|[[:human genes:k:kiaa1033|KIAA1033]]|0.499|
|[[:human genes:c:commd9|COMMD9]]|0.495|
|[[:human genes:a:actr2|ACTR2]]|0.485|
|[[:human genes:c:commd3|COMMD3]]|0.478|
|[[:human genes:k:kiaa0196|KIAA0196]]|0.476|
|[[:human genes:c:ccdc22|CCDC22]]|0.436|
|[[:human genes:v:vps29|VPS29]]|0.436|
|[[:human genes:c:commd4|COMMD4]]|0.43|
|[[:human genes:c:commd10|COMMD10]]|0.424|
|[[:human genes:c:ccdc53|CCDC53]]|0.422|
|[[:human genes:l:lzic|LZIC]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7556
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COMMD7 Expression in NALM6 Cells: 4.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>