COMP [The Human Chemical-Genetic Interaction Map Project]

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======= COMP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COMP
  * **<color #00a2e8>Official Name</color>**: cartilage oligomeric matrix protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1311|1311]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49747|P49747]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COMP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COMP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16051604, ECO:0000269|PubMed:16542502, ECO:0000269|PubMed:17993464}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COMP|
|TSP C|
|EGF CA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|animal organ senescence|
|positive regulation of chondrocyte proliferation|
|tendon development|
|vascular smooth muscle cell development|
|chondrocyte proliferation|
|BMP binding|
|proteoglycan binding|
|vascular smooth muscle cell differentiation|
|vascular smooth muscle contraction|
|heparan sulfate proteoglycan binding|
|vasoconstriction|
|smooth muscle cell differentiation|
|growth plate cartilage development|
|multicellular organism aging|
|negative regulation of blood vessel diameter|
|endochondral bone growth|
|musculoskeletal movement|
|multicellular organismal movement|
|chondrocyte development|
|platelet aggregation|
|bone growth|
|cartilage development involved in endochondral bone morphogenesis|
|collagen fibril organization|
|bone mineralization|
|negative regulation of hemostasis|
|smooth muscle contraction|
|muscle fiber development|
|homotypic cell-cell adhesion|
|artery morphogenesis|
|collagen binding|
|endochondral bone morphogenesis|
|regulation of bone mineralization|
|regulation of hemostasis|
|chondrocyte differentiation|
|multicellular organism growth|
|artery development|
|BMP signaling pathway|
|regulation of biomineralization|
|biomineralization|
|regulation of biomineral tissue development|
|biomineral tissue development|
|organ growth|
|protease binding|
|response to BMP|
|cellular response to BMP stimulus|
|neuromuscular process|
|bone morphogenesis|
|integrin binding|
|extracellular matrix structural constituent|
|striated muscle cell development|
|platelet activation|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|muscle cell development|
|protein secretion|
|protein processing|
|establishment of protein localization to extracellular region|
|response to unfolded protein|
|protein localization to extracellular region|
|vascular process in circulatory system|
|heparin binding|
|cartilage development|
|peptide secretion|
|appendage development|
|limb development|
|response to topologically incorrect protein|
|regulation of ossification|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|striated muscle cell differentiation|
|connective tissue development|
|protein maturation|
|extracellular matrix|
|skeletal system morphogenesis|
|muscle cell differentiation|
|muscle contraction|
|ossification|
|aging|
|blood coagulation|
|coagulation|
|hemostasis|
|muscle system process|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|skin development|
|extracellular structure organization|
|developmental growth|
|blood circulation|
|growth|
|circulatory system process|
|blood vessel morphogenesis|
|supramolecular fiber organization|
|muscle structure development|
|wound healing|
|blood vessel development|
|skeletal system development|
|regulation of body fluid levels|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|response to growth factor|
|cell population proliferation|
|response to wounding|
|protein-containing complex|
|tube morphogenesis|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|tube development|
|circulatory system development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|negative regulation of cell death|
|secretion by cell|
|export from cell|
|programmed cell death|
|cell activation|
|cell death|
|secretion|
|cellular response to endogenous stimulus|
|proteolysis|
|nervous system process|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|extracellular space|
|establishment of protein localization|
|regulation of cell population proliferation|
|cell development|
|regulation of cell death|
|tissue development|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|extracellular region|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.72|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.78|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4872
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COMP Expression in NALM6 Cells: 1.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>