COMT [The Human Chemical-Genetic Interaction Map Project]

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======= COMT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COMT
  * **<color #00a2e8>Official Name</color>**: catechol-O-methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1312|1312]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21964|P21964]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COMT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COMT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116790|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. {ECO:0000269|PubMed:21846718}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 3|
|Methyltransf 18|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of homocysteine metabolic process|
|positive regulation of sulfur amino acid metabolic process|
|cellular response to phosphate starvation|
|orcinol O-methyltransferase activity|
|catechol O-methyltransferase activity|
|L-dopa O-methyltransferase activity|
|regulation of homocysteine metabolic process|
|positive regulation of cellular amino acid metabolic process|
|positive regulation of sulfur metabolic process|
|regulation of sulfur amino acid metabolic process|
|negative regulation of renal sodium excretion|
|negative regulation of catecholamine metabolic process|
|negative regulation of dopamine metabolic process|
|negative regulation of cellular amine metabolic process|
|dopamine catabolic process|
|O-methyltransferase activity|
|catechol-containing compound catabolic process|
|catecholamine catabolic process|
|short-term memory|
|positive regulation of cellular amine metabolic process|
|phenol-containing compound catabolic process|
|regulation of sulfur metabolic process|
|regulation of dopamine metabolic process|
|regulation of catecholamine metabolic process|
|regulation of renal sodium excretion|
|neurotransmitter catabolic process|
|regulation of excretion|
|dopamine metabolic process|
|response to pain|
|estrogen metabolic process|
|regulation of renal system process|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|catechol-containing compound metabolic process|
|catecholamine metabolic process|
|negative regulation of smooth muscle cell proliferation|
|methyltransferase activity|
|regulation of cellular amino acid metabolic process|
|multicellular organismal response to stress|
|cell body|
|organic hydroxy compound catabolic process|
|response to estrogen|
|regulation of cellular amine metabolic process|
|phenol-containing compound metabolic process|
|neurotransmitter metabolic process|
|memory|
|cellular hormone metabolic process|
|regulation of smooth muscle cell proliferation|
|regulation of nervous system process|
|positive regulation of small molecule metabolic process|
|drug catabolic process|
|learning|
|dendritic spine|
|cellular response to starvation|
|regulation of cellular ketone metabolic process|
|female pregnancy|
|ammonium ion metabolic process|
|response to starvation|
|postsynaptic membrane|
|hormone metabolic process|
|multi-multicellular organism process|
|magnesium ion binding|
|negative regulation of secretion|
|cellular response to nutrient levels|
|learning or memory|
|steroid metabolic process|
|cellular response to extracellular stimulus|
|axon|
|cognition|
|methylation|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|cellular response to external stimulus|
|regulation of neurotransmitter levels|
|dendrite|
|regulation of small molecule metabolic process|
|aromatic compound catabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|negative regulation of transport|
|response to nutrient levels|
|drug metabolic process|
|response to extracellular stimulus|
|regulation of hormone levels|
|behavior|
|regulation of system process|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|response to bacterium|
|regulation of secretion|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to lipid|
|response to organic cyclic compound|
|multi-organism reproductive process|
|response to drug|
|organonitrogen compound catabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|nervous system process|
|reproductive process|
|reproduction|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.437|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3964
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COMT Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>