COPA [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= COPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COPA
  * **<color #00a2e8>Official Name</color>**: COPI coat complex subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1314|1314]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53621|P53621]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601924|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COPI C|
|Coatomer WDAD|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pancreatic juice secretion|
|COPI vesicle coat|
|secretion by tissue|
|intra-Golgi vesicle-mediated transport|
|digestive system process|
|body fluid secretion|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|transport vesicle|
|hormone activity|
|digestion|
|structural molecule activity|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|Golgi vesicle transport|
|regulation of body fluid levels|
|Golgi membrane|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|extracellular space|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.95|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.53|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.39|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.37|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.35|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.26|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.23|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.09|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.05|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.04|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.99|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.96|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.93|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.89|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.83|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.8|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.77|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.76|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.75|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.75|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.73|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.71|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.71|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.71|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.74|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.79|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.81|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.82|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.85|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.88|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.97|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:copg1|COPG1]]|0.587|
|[[:human genes:c:chd4|CHD4]]|0.567|
|[[:human genes:d:disp2|DISP2]]|0.548|
|[[:human genes:c:c14orf93|C14orf93]]|0.52|
|[[:human genes:c:copz1|COPZ1]]|0.519|
|[[:human genes:p:psmd11|PSMD11]]|0.519|
|[[:human genes:v:vasn|VASN]]|0.515|
|[[:human genes:m:med14|MED14]]|0.502|
|[[:human genes:t:tfip11|TFIP11]]|0.501|
|[[:human genes:n:napa|NAPA]]|0.494|
|[[:human genes:p:psmb4|PSMB4]]|0.493|
|[[:human genes:s:slc4a1|SLC4A1]]|0.493|
|[[:human genes:v:vps54|VPS54]]|0.492|
|[[:human genes:d:ddtl|DDTL]]|0.492|
|[[:human genes:c:copb2|COPB2]]|0.49|
|[[:human genes:t:ticrr|TICRR]]|0.49|
|[[:human genes:n:nsf|NSF]]|0.487|
|[[:human genes:r:ranbp2|RANBP2]]|0.486|
|[[:human genes:a:akirin2|AKIRIN2]]|0.483|
|[[:human genes:a:arcn1|ARCN1]]|0.481|
|[[:human genes:p:pan3|PAN3]]|0.48|
|[[:human genes:m:myo1h|MYO1H]]|0.479|
|[[:human genes:h:hap1|HAP1]]|0.478|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.478|
|[[:human genes:v:vps52|VPS52]]|0.473|
|[[:human genes:m:mt1e|MT1E]]|0.472|
|[[:human genes:n:nupl1|NUPL1]]|0.472|
|[[:human genes:z:znf106|ZNF106]]|0.469|
|[[:human genes:a:aamp|AAMP]]|0.469|
|[[:human genes:t:tceb3c|TCEB3C]]|0.468|
|[[:human genes:s:smg1|SMG1]]|0.467|
|[[:human genes:g:golga8o|GOLGA8O]]|0.466|
|[[:human genes:o:osbp|OSBP]]|0.465|
|[[:human genes:f:fam160a1|FAM160A1]]|0.464|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.462|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.461|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.461|
|[[:human genes:o:orc1|ORC1]]|0.46|
|[[:human genes:d:dhx38|DHX38]]|0.459|
|[[:human genes:n:npipb5|NPIPB5]]|0.456|
|[[:human genes:t:twistnb|TWISTNB]]|0.455|
|[[:human genes:u:utp3|UTP3]]|0.455|
|[[:human genes:d:ddt|DDT]]|0.455|
|[[:human genes:z:znf541|ZNF541]]|0.454|
|[[:human genes:c:cbwd3|CBWD3]]|0.45|
|[[:human genes:z:zfand5|ZFAND5]]|0.449|
|[[:human genes:s:supt5h|SUPT5H]]|0.449|
|[[:human genes:r:rbm39|RBM39]]|0.449|
|[[:human genes:d:dnm2|DNM2]]|0.448|
|[[:human genes:x:xab2|XAB2]]|0.446|
|[[:human genes:r:rps20|RPS20]]|0.446|
|[[:human genes:c:ccdc94|CCDC94]]|0.446|
|[[:human genes:s:sf3a1|SF3A1]]|0.445|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.445|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.444|
|[[:human genes:c:copb1|COPB1]]|0.444|
|[[:human genes:d:dock6|DOCK6]]|0.444|
|[[:human genes:p:psmd3|PSMD3]]|0.443|
|[[:human genes:p:psmc5|PSMC5]]|0.443|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.443|
|[[:human genes:n:nup160|NUP160]]|0.443|
|[[:human genes:p:pcf11|PCF11]]|0.443|
|[[:human genes:p:pola1|POLA1]]|0.442|
|[[:human genes:s:slc6a17|SLC6A17]]|0.442|
|[[:human genes:o:or10g3|OR10G3]]|0.442|
|[[:human genes:a:aqr|AQR]]|0.44|
|[[:human genes:r:rbbp5|RBBP5]]|0.439|
|[[:human genes:t:tsg101|TSG101]]|0.438|
|[[:human genes:t:timeless|TIMELESS]]|0.438|
|[[:human genes:r:rfxank|RFXANK]]|0.438|
|[[:human genes:p:pigs|PIGS]]|0.438|
|[[:human genes:c:cdc73|CDC73]]|0.437|
|[[:human genes:n:nbpf16|NBPF16]]|0.436|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.435|
|[[:human genes:n:nol8|NOL8]]|0.434|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.434|
|[[:human genes:o:orc6|ORC6]]|0.432|
|[[:human genes:t:tuba8|TUBA8]]|0.431|
|[[:human genes:d:dtl|DTL]]|0.431|
|[[:human genes:p:pan2|PAN2]]|0.431|
|[[:human genes:a:ankle2|ANKLE2]]|0.431|
|[[:human genes:p:prim1|PRIM1]]|0.431|
|[[:human genes:a:atp1a3|ATP1A3]]|0.431|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.43|
|[[:human genes:p:psmb2|PSMB2]]|0.43|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.43|
|[[:human genes:p:psma6|PSMA6]]|0.43|
|[[:human genes:r:rps2|RPS2]]|0.43|
|[[:human genes:c:cope|COPE]]|0.429|
|[[:human genes:p:paf1|PAF1]]|0.427|
|[[:human genes:c:cdca3|CDCA3]]|0.426|
|[[:human genes:r:rpl6|RPL6]]|0.426|
|[[:human genes:m:myh7b|MYH7B]]|0.426|
|[[:human genes:s:snip1|SNIP1]]|0.425|
|[[:human genes:k:kif3c|KIF3C]]|0.425|
|[[:human genes:s:sf3a3|SF3A3]]|0.424|
|[[:human genes:c:cdca5|CDCA5]]|0.424|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.423|
|[[:human genes:t:tpx2|TPX2]]|0.423|
|[[:human genes:c:cbwd5|CBWD5]]|0.423|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.422|
|[[:human genes:p:psmc6|PSMC6]]|0.422|
|[[:human genes:k:kctd17|KCTD17]]|0.421|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.421|
|[[:human genes:a:aatf|AATF]]|0.42|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.42|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.419|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.419|
|[[:human genes:z:znf830|ZNF830]]|0.418|
|[[:human genes:v:vps51|VPS51]]|0.418|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.418|
|[[:human genes:f:fbxw9|FBXW9]]|0.418|
|[[:human genes:n:nup85|NUP85]]|0.418|
|[[:human genes:s:strn|STRN]]|0.418|
|[[:human genes:c:cbwd6|CBWD6]]|0.418|
|[[:human genes:w:wdr87|WDR87]]|0.417|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.417|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.417|
|[[:human genes:b:brd2|BRD2]]|0.417|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.417|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.416|
|[[:human genes:c:cactin|CACTIN]]|0.416|
|[[:human genes:c:ctr9|CTR9]]|0.415|
|[[:human genes:p:psmc2|PSMC2]]|0.415|
|[[:human genes:m:myo18a|MYO18A]]|0.414|
|[[:human genes:p:ppp1r13l|PPP1R13L]]|0.414|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.414|
|[[:human genes:t:trappc11|TRAPPC11]]|0.413|
|[[:human genes:c:cln6|CLN6]]|0.412|
|[[:human genes:s:stil|STIL]]|0.411|
|[[:human genes:c:cdc6|CDC6]]|0.411|
|[[:human genes:p:psmd7|PSMD7]]|0.411|
|[[:human genes:t:terf2|TERF2]]|0.41|
|[[:human genes:t:topbp1|TOPBP1]]|0.41|
|[[:human genes:g:gid4|GID4]]|0.41|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.409|
|[[:human genes:n:narfl|NARFL]]|0.409|
|[[:human genes:s:snrpa1|SNRPA1]]|0.408|
|[[:human genes:p:pola2|POLA2]]|0.407|
|[[:human genes:z:znf655|ZNF655]]|0.407|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.406|
|[[:human genes:r:rnf113a|RNF113A]]|0.404|
|[[:human genes:g:gar1|GAR1]]|0.404|
|[[:human genes:p:pwp2|PWP2]]|0.404|
|[[:human genes:s:ssfa2|SSFA2]]|0.403|
|[[:human genes:g:golga6a|GOLGA6A]]|0.403|
|[[:human genes:r:rps12|RPS12]]|0.403|
|[[:human genes:t:tyms|TYMS]]|0.403|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.403|
|[[:human genes:c:ccna2|CCNA2]]|0.403|
|[[:human genes:a:acsf2|ACSF2]]|0.402|
|[[:human genes:d:ddx51|DDX51]]|0.402|
|[[:human genes:u:ubap1|UBAP1]]|0.402|
|[[:human genes:m:med17|MED17]]|0.401|
|[[:human genes:p:polr2f|POLR2F]]|0.401|
|[[:human genes:r:rad21|RAD21]]|0.4|
|[[:human genes:m:myb|MYB]]|0.4|
|[[:human genes:e:ell|ELL]]|0.4|
|[[:human genes:h:hinfp|HINFP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 735/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 989
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COPA Expression in NALM6 Cells: 7.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>