COPE [The Human Chemical-Genetic Interaction Map Project]

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======= COPE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COPE
  * **<color #00a2e8>Official Name</color>**: COPI coat complex subunit epsilon
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11316|11316]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14579|O14579]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COPE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606942|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP- ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Coatomer E|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPI vesicle coat|
|intra-Golgi vesicle-mediated transport|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|transport vesicle|
|structural molecule activity|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|Golgi vesicle transport|
|Golgi membrane|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-3.1|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.58|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.52|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.29|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.25|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.23|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.09|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.07|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.03|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.01|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.99|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.98|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.96|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.93|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.92|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.9|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.89|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.89|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.83|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.82|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.8|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.8|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.79|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.76|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.74|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.72|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.71|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.7|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.72|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.74|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.74|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.76|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.78|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.82|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.83|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.85|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.91|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.03|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|2.05|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.06|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.09|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.11|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.23|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.26|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.3|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.34|
|[[:results:exp331|A-769662 20μM R07 exp331]]|2.41|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.68|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|2.76|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.79|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.86|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.98|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|3.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.622|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.558|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.556|
|[[:human genes:o:orc1|ORC1]]|0.547|
|[[:human genes:n:npipb8|NPIPB8]]|0.537|
|[[:human genes:s:syt9|SYT9]]|0.534|
|[[:human genes:s:supt6h|SUPT6H]]|0.532|
|[[:human genes:r:rps9|RPS9]]|0.527|
|[[:human genes:t:tceb3c|TCEB3C]]|0.527|
|[[:human genes:c:cdc73|CDC73]]|0.526|
|[[:human genes:c:c14orf93|C14orf93]]|0.522|
|[[:human genes:c:cdca3|CDCA3]]|0.521|
|[[:human genes:n:npipb5|NPIPB5]]|0.519|
|[[:human genes:r:rad21|RAD21]]|0.511|
|[[:human genes:t:tfip11|TFIP11]]|0.511|
|[[:human genes:g:gar1|GAR1]]|0.51|
|[[:human genes:g:golga8o|GOLGA8O]]|0.51|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.509|
|[[:human genes:g:golga6a|GOLGA6A]]|0.508|
|[[:human genes:c:cbwd3|CBWD3]]|0.508|
|[[:human genes:p:psmd11|PSMD11]]|0.508|
|[[:human genes:m:myo1h|MYO1H]]|0.508|
|[[:human genes:c:chd4|CHD4]]|0.504|
|[[:human genes:u:upf1|UPF1]]|0.502|
|[[:human genes:c:cbwd6|CBWD6]]|0.5|
|[[:human genes:c:chaf1a|CHAF1A]]|0.5|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.498|
|[[:human genes:c:ckap5|CKAP5]]|0.498|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.498|
|[[:human genes:c:cbwd5|CBWD5]]|0.496|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.495|
|[[:human genes:m:mt1e|MT1E]]|0.495|
|[[:human genes:p:psmd3|PSMD3]]|0.493|
|[[:human genes:r:rpl37a|RPL37A]]|0.492|
|[[:human genes:a:arcn1|ARCN1]]|0.491|
|[[:human genes:p:psmb2|PSMB2]]|0.49|
|[[:human genes:p:psma6|PSMA6]]|0.49|
|[[:human genes:c:cgb2|CGB2]]|0.487|
|[[:human genes:c:cmya5|CMYA5]]|0.487|
|[[:human genes:p:psmd1|PSMD1]]|0.486|
|[[:human genes:r:rps28|RPS28]]|0.486|
|[[:human genes:t:ticrr|TICRR]]|0.485|
|[[:human genes:p:pole|POLE]]|0.484|
|[[:human genes:p:pwp2|PWP2]]|0.483|
|[[:human genes:p:paf1|PAF1]]|0.483|
|[[:human genes:t:twistnb|TWISTNB]]|0.482|
|[[:human genes:p:psmc6|PSMC6]]|0.482|
|[[:human genes:p:psmb4|PSMB4]]|0.481|
|[[:human genes:m:mdm2|MDM2]]|0.481|
|[[:human genes:s:slc4a1|SLC4A1]]|0.481|
|[[:human genes:p:psmc1|PSMC1]]|0.481|
|[[:human genes:s:sf3a1|SF3A1]]|0.481|
|[[:human genes:z:znf830|ZNF830]]|0.479|
|[[:human genes:d:ddtl|DDTL]]|0.479|
|[[:human genes:r:rpl35|RPL35]]|0.479|
|[[:human genes:i:igfn1|IGFN1]]|0.479|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.477|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.477|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.477|
|[[:human genes:c:cnot1|CNOT1]]|0.476|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.475|
|[[:human genes:s:snrpa1|SNRPA1]]|0.474|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.472|
|[[:human genes:c:copg1|COPG1]]|0.472|
|[[:human genes:r:rrp15|RRP15]]|0.471|
|[[:human genes:s:smg7|SMG7]]|0.467|
|[[:human genes:n:nupl1|NUPL1]]|0.466|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.466|
|[[:human genes:l:lrr1|LRR1]]|0.466|
|[[:human genes:p:psmd7|PSMD7]]|0.466|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.466|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.463|
|[[:human genes:p:prmt8|PRMT8]]|0.463|
|[[:human genes:n:nup155|NUP155]]|0.462|
|[[:human genes:r:rps12|RPS12]]|0.461|
|[[:human genes:f:fam20a|FAM20A]]|0.461|
|[[:human genes:s:stil|STIL]]|0.46|
|[[:human genes:t:trim52|TRIM52]]|0.458|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.458|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.458|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.458|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.457|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.457|
|[[:human genes:c:copb2|COPB2]]|0.456|
|[[:human genes:m:madcam1|MADCAM1]]|0.455|
|[[:human genes:r:rps14|RPS14]]|0.454|
|[[:human genes:c:cdc45|CDC45]]|0.454|
|[[:human genes:z:znf655|ZNF655]]|0.454|
|[[:human genes:w:wdr43|WDR43]]|0.451|
|[[:human genes:c:ccdc94|CCDC94]]|0.451|
|[[:human genes:a:abhd8|ABHD8]]|0.45|
|[[:human genes:c:ccna2|CCNA2]]|0.449|
|[[:human genes:p:pan3|PAN3]]|0.449|
|[[:human genes:t:tuba8|TUBA8]]|0.449|
|[[:human genes:r:rrn3|RRN3]]|0.448|
|[[:human genes:r:rps2|RPS2]]|0.448|
|[[:human genes:m:msh5|MSH5]]|0.447|
|[[:human genes:p:pola1|POLA1]]|0.447|
|[[:human genes:d:dtl|DTL]]|0.446|
|[[:human genes:r:riok2|RIOK2]]|0.445|
|[[:human genes:c:cnpy3|CNPY3]]|0.444|
|[[:human genes:t:tpx2|TPX2]]|0.444|
|[[:human genes:p:psmc2|PSMC2]]|0.443|
|[[:human genes:s:sfpq|SFPQ]]|0.443|
|[[:human genes:a:aqr|AQR]]|0.443|
|[[:human genes:r:rps3a|RPS3A]]|0.442|
|[[:human genes:r:rpsa|RPSA]]|0.441|
|[[:human genes:a:aamp|AAMP]]|0.441|
|[[:human genes:n:nup93|NUP93]]|0.441|
|[[:human genes:k:kif3c|KIF3C]]|0.441|
|[[:human genes:d:dock6|DOCK6]]|0.44|
|[[:human genes:k:kctd17|KCTD17]]|0.44|
|[[:human genes:n:nup160|NUP160]]|0.439|
|[[:human genes:h:hap1|HAP1]]|0.438|
|[[:human genes:p:pold1|POLD1]]|0.438|
|[[:human genes:e:exosc5|EXOSC5]]|0.438|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.438|
|[[:human genes:l:lad1|LAD1]]|0.437|
|[[:human genes:p:psmc3|PSMC3]]|0.437|
|[[:human genes:z:zfand5|ZFAND5]]|0.436|
|[[:human genes:c:ctage4|CTAGE4]]|0.436|
|[[:human genes:n:nol10|NOL10]]|0.436|
|[[:human genes:m:mfsd12|MFSD12]]|0.436|
|[[:human genes:d:ddx47|DDX47]]|0.435|
|[[:human genes:s:supt5h|SUPT5H]]|0.435|
|[[:human genes:l:loc643669|LOC643669]]|0.434|
|[[:human genes:t:tsg101|TSG101]]|0.434|
|[[:human genes:n:npipb9|NPIPB9]]|0.433|
|[[:human genes:c:col2a1|COL2A1]]|0.431|
|[[:human genes:c:copb1|COPB1]]|0.431|
|[[:human genes:a:acsf2|ACSF2]]|0.431|
|[[:human genes:s:slc5a5|SLC5A5]]|0.43|
|[[:human genes:a:akirin2|AKIRIN2]]|0.43|
|[[:human genes:h:hcfc1|HCFC1]]|0.43|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.429|
|[[:human genes:p:pola2|POLA2]]|0.429|
|[[:human genes:k:krt78|KRT78]]|0.429|
|[[:human genes:c:copa|COPA]]|0.429|
|[[:human genes:p:pitpnm3|PITPNM3]]|0.428|
|[[:human genes:l:lipe|LIPE]]|0.428|
|[[:human genes:m:med17|MED17]]|0.427|
|[[:human genes:m:myh2|MYH2]]|0.427|
|[[:human genes:r:rps19|RPS19]]|0.427|
|[[:human genes:c:c3|C3]]|0.427|
|[[:human genes:r:rnf4|RNF4]]|0.427|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.426|
|[[:human genes:a:ankle2|ANKLE2]]|0.426|
|[[:human genes:p:psap|PSAP]]|0.425|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.425|
|[[:human genes:w:wdr75|WDR75]]|0.424|
|[[:human genes:w:wdr87|WDR87]]|0.423|
|[[:human genes:n:nbpf16|NBPF16]]|0.423|
|[[:human genes:i:iscu|ISCU]]|0.422|
|[[:human genes:s:sap30bp|SAP30BP]]|0.42|
|[[:human genes:s:sec13|SEC13]]|0.42|
|[[:human genes:a:adra1d|ADRA1D]]|0.418|
|[[:human genes:c:cox8a|COX8A]]|0.418|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.418|
|[[:human genes:r:rrp1|RRP1]]|0.418|
|[[:human genes:p:psmd6|PSMD6]]|0.418|
|[[:human genes:c:cdh24|CDH24]]|0.418|
|[[:human genes:n:nup133|NUP133]]|0.417|
|[[:human genes:r:rrp7a|RRP7A]]|0.417|
|[[:human genes:s:ssh2|SSH2]]|0.416|
|[[:human genes:r:rbm39|RBM39]]|0.416|
|[[:human genes:m:myo18a|MYO18A]]|0.416|
|[[:human genes:n:nup205|NUP205]]|0.415|
|[[:human genes:s:scaf1|SCAF1]]|0.415|
|[[:human genes:s:sel1l|SEL1L]]|0.414|
|[[:human genes:a:aaas|AAAS]]|0.414|
|[[:human genes:n:nup153|NUP153]]|0.413|
|[[:human genes:s:s1pr4|S1PR4]]|0.413|
|[[:human genes:s:sf3a2|SF3A2]]|0.412|
|[[:human genes:x:xylt2|XYLT2]]|0.412|
|[[:human genes:p:pan2|PAN2]]|0.411|
|[[:human genes:u:utp20|UTP20]]|0.411|
|[[:human genes:u:urb2|URB2]]|0.411|
|[[:human genes:p:psmd2|PSMD2]]|0.411|
|[[:human genes:p:pdcd11|PDCD11]]|0.41|
|[[:human genes:x:xab2|XAB2]]|0.41|
|[[:human genes:r:rad51|RAD51]]|0.409|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.409|
|[[:human genes:p:ppfia4|PPFIA4]]|0.409|
|[[:human genes:d:dnm2|DNM2]]|0.409|
|[[:human genes:c:cln6|CLN6]]|0.408|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.407|
|[[:human genes:z:znf106|ZNF106]]|0.407|
|[[:human genes:p:prim1|PRIM1]]|0.407|
|[[:human genes:p:psmc4|PSMC4]]|0.407|
|[[:human genes:r:rps5|RPS5]]|0.407|
|[[:human genes:o:or11h6|OR11H6]]|0.407|
|[[:human genes:o:ogfr|OGFR]]|0.407|
|[[:human genes:s:specc1l|SPECC1L]]|0.407|
|[[:human genes:p:psmc5|PSMC5]]|0.406|
|[[:human genes:s:smg1|SMG1]]|0.406|
|[[:human genes:f:fam160a1|FAM160A1]]|0.406|
|[[:human genes:h:hivep3|HIVEP3]]|0.406|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.405|
|[[:human genes:s:slc6a17|SLC6A17]]|0.404|
|[[:human genes:n:nup107|NUP107]]|0.404|
|[[:human genes:m:myb|MYB]]|0.404|
|[[:human genes:n:nfatc4|NFATC4]]|0.404|
|[[:human genes:f:fancm|FANCM]]|0.403|
|[[:human genes:n:nop16|NOP16]]|0.403|
|[[:human genes:a:aco2|ACO2]]|0.403|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.402|
|[[:human genes:e:exd1|EXD1]]|0.401|
|[[:human genes:s:slc7a6os|SLC7A6OS]]|0.401|
|[[:human genes:p:pbxip1|PBXIP1]]|0.401|
|[[:human genes:e:exosc6|EXOSC6]]|0.401|
|[[:human genes:n:nup62|NUP62]]|0.401|
|[[:human genes:r:rffl|RFFL]]|0.4|
|[[:human genes:o:orc6|ORC6]]|0.4|
|[[:human genes:c:cwc22|CWC22]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 525/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|21/28|
|bone|18/26|
|breast|18/33|
|central nervous system|35/56|
|cervix|4/4|
|colorectal|12/17|
|esophagus|11/13|
|fibroblast|0/1|
|gastric|13/16|
|kidney|19/21|
|liver|16/20|
|lung|53/75|
|lymphocyte|12/16|
|ovary|19/26|
|pancreas|18/24|
|peripheral nervous system|3/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|11/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|18/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 213
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COPE Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>