COPS2 [The Human Chemical-Genetic Interaction Map Project]

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======= COPS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COPS2
  * **<color #00a2e8>Official Name</color>**: COP9 signalosome subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9318|9318]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61201|P61201]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COPS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604508|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PCI Csn8|
|PCI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein deneddylation|
|inner cell mass cell proliferation|
|blastocyst growth|
|nucleotide-excision repair, DNA damage recognition|
|COP9 signalosome|
|skeletal muscle cell differentiation|
|transcription-coupled nucleotide-excision repair|
|blastocyst development|
|nucleotide-excision repair|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|transcription corepressor activity|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|protein modification by small protein removal|
|post-translational protein modification|
|in utero embryonic development|
|developmental growth|
|growth|
|muscle structure development|
|transcription by RNA polymerase II|
|DNA repair|
|cell population proliferation|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|protein phosphorylation|
|embryo development|
|protein modification by small protein conjugation or removal|
|neuron differentiation|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|tissue development|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.95|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.84|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.84|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.77|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.77|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.74|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.72|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.84|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.84|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.95|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.01|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|6.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cops4|COPS4]]|0.557|
|[[:human genes:c:cops7b|COPS7B]]|0.516|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 79/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|3/28|
|bone|1/26|
|breast|4/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|4/21|
|liver|2/20|
|lung|10/75|
|lymphocyte|1/16|
|ovary|4/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1281
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COPS2 Expression in NALM6 Cells: 5.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>