COPS4 [The Human Chemical-Genetic Interaction Map Project]

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======= COPS4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COPS4
  * **<color #00a2e8>Official Name</color>**: COP9 signalosome subunit 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51138|51138]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BT78|Q9BT78]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COPS4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPS4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616008|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PCI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NEDD8-specific protease activity|
|protein deneddylation|
|nucleotide-excision repair, DNA damage recognition|
|COP9 signalosome|
|transcription-coupled nucleotide-excision repair|
|nucleotide-excision repair|
|synaptic vesicle|
|protein modification by small protein removal|
|post-translational protein modification|
|nuclear speck|
|DNA repair|
|cell junction|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|proteolysis|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.93|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.89|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.88|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.81|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.89|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.94|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.16|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.82|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|5.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cops2|COPS2]]|0.557|
|[[:human genes:c:cops7b|COPS7B]]|0.53|
|[[:human genes:c:cops8|COPS8]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 538/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|17/28|
|bone|18/26|
|breast|27/33|
|central nervous system|31/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|11/13|
|fibroblast|0/1|
|gastric|13/16|
|kidney|19/21|
|liver|17/20|
|lung|57/75|
|lymphocyte|8/16|
|ovary|25/26|
|pancreas|19/24|
|peripheral nervous system|8/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|8/9|
|thyroid|0/2|
|upper aerodigestive|18/22|
|urinary tract|23/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1471
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COPS4 Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>