COPS5 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= COPS5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COPS5
  * **<color #00a2e8>Official Name</color>**: COP9 signalosome subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10987|10987]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92905|Q92905]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COPS5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPS5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mov34|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|macrophage migration inhibitory factor binding|
|exosomal secretion|
|extracellular exosome biogenesis|
|NEDD8-specific protease activity|
|extracellular vesicle biogenesis|
|protein deneddylation|
|regulation of IRE1-mediated unfolded protein response|
|eukaryotic translation initiation factor 3 complex|
|nucleotide-excision repair, DNA damage recognition|
|regulation of endoplasmic reticulum unfolded protein response|
|COP9 signalosome|
|translation initiation factor activity|
|metallopeptidase activity|
|transcription-coupled nucleotide-excision repair|
|regulation of response to endoplasmic reticulum stress|
|metalloendopeptidase activity|
|thiol-dependent ubiquitin-specific protease activity|
|nucleotide-excision repair|
|chromatin|
|synaptic vesicle|
|translational initiation|
|regulation of JNK cascade|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|positive regulation of DNA-binding transcription factor activity|
|protein deubiquitination|
|transcription coactivator activity|
|protein modification by small protein removal|
|enzyme binding|
|post-translational protein modification|
|translation|
|peptide biosynthetic process|
|regulation of DNA-binding transcription factor activity|
|transcription by RNA polymerase II|
|DNA repair|
|amide biosynthetic process|
|peptide metabolic process|
|cell junction|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|perinuclear region of cytoplasm|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of MAPK cascade|
|cellular response to DNA damage stimulus|
|cellular amide metabolic process|
|exocytosis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|secretion by cell|
|export from cell|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|proteolysis|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.99|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.86|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.77|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.73|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.71|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.71|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.7|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.74|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.88|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.88|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.95|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cops7b|COPS7B]]|0.514|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 704/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/25|
|breast|31/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|14/14|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1170
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COPS5 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>