COPZ1 [The Human Chemical-Genetic Interaction Map Project]

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======= COPZ1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COPZ1
  * **<color #00a2e8>Official Name</color>**: COPI coat complex subunit zeta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22818|22818]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61923|P61923]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COPZ1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPZ1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615472|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Clat adaptor s|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPI vesicle coat|
|intra-Golgi vesicle-mediated transport|
|toxin transport|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|transport vesicle|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|Golgi vesicle transport|
|Golgi membrane|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.79|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.68|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.38|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.35|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.29|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.25|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.22|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.1|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.06|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.9|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.81|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.79|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.74|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.71|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.73|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.76|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.79|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.79|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.8|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.83|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.85|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.95|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.05|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|2.09|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|2.17|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:copb2|COPB2]]|0.593|
|[[:human genes:v:vps54|VPS54]]|0.563|
|[[:human genes:c:copg1|COPG1]]|0.556|
|[[:human genes:c:copa|COPA]]|0.519|
|[[:human genes:o:osbp|OSBP]]|0.506|
|[[:human genes:c:cbwd5|CBWD5]]|0.495|
|[[:human genes:c:chmp4b|CHMP4B]]|0.484|
|[[:human genes:r:rad51|RAD51]]|0.483|
|[[:human genes:c:copb1|COPB1]]|0.479|
|[[:human genes:c:cbwd3|CBWD3]]|0.478|
|[[:human genes:d:dtl|DTL]]|0.478|
|[[:human genes:p:prim1|PRIM1]]|0.478|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.474|
|[[:human genes:s:supt5h|SUPT5H]]|0.473|
|[[:human genes:p:psmb4|PSMB4]]|0.469|
|[[:human genes:a:arcn1|ARCN1]]|0.469|
|[[:human genes:n:nup160|NUP160]]|0.468|
|[[:human genes:r:ranbp2|RANBP2]]|0.468|
|[[:human genes:c:cbwd6|CBWD6]]|0.466|
|[[:human genes:u:utp3|UTP3]]|0.463|
|[[:human genes:p:polr2f|POLR2F]]|0.462|
|[[:human genes:v:vps52|VPS52]]|0.462|
|[[:human genes:c:c14orf93|C14orf93]]|0.461|
|[[:human genes:a:akirin2|AKIRIN2]]|0.459|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.455|
|[[:human genes:r:rbm39|RBM39]]|0.455|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.453|
|[[:human genes:p:polr2j3|POLR2J3]]|0.451|
|[[:human genes:s:supt6h|SUPT6H]]|0.451|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.448|
|[[:human genes:t:tfip11|TFIP11]]|0.446|
|[[:human genes:n:nsf|NSF]]|0.446|
|[[:human genes:z:znf655|ZNF655]]|0.445|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.445|
|[[:human genes:i:ints6|INTS6]]|0.442|
|[[:human genes:r:rpl34|RPL34]]|0.44|
|[[:human genes:u:upf1|UPF1]]|0.44|
|[[:human genes:m:myo1h|MYO1H]]|0.44|
|[[:human genes:t:trappc11|TRAPPC11]]|0.438|
|[[:human genes:s:sf3a1|SF3A1]]|0.437|
|[[:human genes:h:hap1|HAP1]]|0.435|
|[[:human genes:b:brd2|BRD2]]|0.435|
|[[:human genes:t:tceb3c|TCEB3C]]|0.435|
|[[:human genes:n:nol12|NOL12]]|0.434|
|[[:human genes:n:narfl|NARFL]]|0.433|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.432|
|[[:human genes:n:napa|NAPA]]|0.43|
|[[:human genes:n:npipb5|NPIPB5]]|0.429|
|[[:human genes:c:ccdc94|CCDC94]]|0.429|
|[[:human genes:c:chd4|CHD4]]|0.429|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.427|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.426|
|[[:human genes:a:ankle2|ANKLE2]]|0.425|
|[[:human genes:c:ccna2|CCNA2]]|0.424|
|[[:human genes:i:ints1|INTS1]]|0.423|
|[[:human genes:r:rps2|RPS2]]|0.423|
|[[:human genes:c:cdc45|CDC45]]|0.422|
|[[:human genes:s:slc4a1|SLC4A1]]|0.422|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.421|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.421|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.421|
|[[:human genes:v:vasn|VASN]]|0.421|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.421|
|[[:human genes:r:rrp15|RRP15]]|0.419|
|[[:human genes:n:nupl1|NUPL1]]|0.419|
|[[:human genes:t:timeless|TIMELESS]]|0.418|
|[[:human genes:s:snip1|SNIP1]]|0.418|
|[[:human genes:s:scaf1|SCAF1]]|0.417|
|[[:human genes:s:slc38a7|SLC38A7]]|0.417|
|[[:human genes:t:tsg101|TSG101]]|0.416|
|[[:human genes:o:or10g3|OR10G3]]|0.416|
|[[:human genes:u:utp20|UTP20]]|0.415|
|[[:human genes:r:rpl14|RPL14]]|0.415|
|[[:human genes:p:pan3|PAN3]]|0.415|
|[[:human genes:p:pex5|PEX5]]|0.414|
|[[:human genes:a:aatf|AATF]]|0.414|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.414|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.413|
|[[:human genes:p:psmc5|PSMC5]]|0.413|
|[[:human genes:r:rpl35|RPL35]]|0.413|
|[[:human genes:f:fam160a1|FAM160A1]]|0.411|
|[[:human genes:g:gosr2|GOSR2]]|0.41|
|[[:human genes:t:ticrr|TICRR]]|0.41|
|[[:human genes:r:rfpl3|RFPL3]]|0.408|
|[[:human genes:r:rnf4|RNF4]]|0.408|
|[[:human genes:o:orc6|ORC6]]|0.408|
|[[:human genes:r:rbbp5|RBBP5]]|0.406|
|[[:human genes:m:med14|MED14]]|0.405|
|[[:human genes:s:slc6a17|SLC6A17]]|0.404|
|[[:human genes:u:ubap1|UBAP1]]|0.404|
|[[:human genes:s:sf3a2|SF3A2]]|0.403|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.403|
|[[:human genes:s:sema6b|SEMA6B]]|0.402|
|[[:human genes:n:nfatc4|NFATC4]]|0.402|
|[[:human genes:l:lrr1|LRR1]]|0.401|
|[[:human genes:p:psma6|PSMA6]]|0.4|
|[[:human genes:m:myb|MYB]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 569/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|26/28|
|bone|18/26|
|breast|28/33|
|central nervous system|41/56|
|cervix|3/4|
|colorectal|11/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|18/21|
|liver|16/20|
|lung|54/75|
|lymphocyte|14/16|
|ovary|21/26|
|pancreas|18/24|
|peripheral nervous system|11/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|25/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1080
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COPZ1 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>