COQ2 [The Human Chemical-Genetic Interaction Map Project]

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======= COQ2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COQ2
  * **<color #00a2e8>Official Name</color>**: coenzyme Q2, polyprenyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27235|27235]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96H96|Q96H96]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COQ2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COQ2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609825|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. {ECO:0000255|HAMAP-Rule:MF_03189, ECO:0000269|PubMed:15153069, ECO:0000269|PubMed:16400613, ECO:0000269|PubMed:17374725, ECO:0000269|PubMed:27493029}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UbiA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|4-hydroxybenzoate nonaprenyltransferase activity|
|4-hydroxybenzoate decaprenyltransferase activity|
|transferase activity, transferring alkyl or aryl (other than methyl) groups|
|quinone biosynthetic process|
|ubiquinone biosynthetic process|
|ubiquinone metabolic process|
|glycerol metabolic process|
|alditol metabolic process|
|isoprenoid biosynthetic process|
|ketone biosynthetic process|
|quinone metabolic process|
|integral component of mitochondrial inner membrane|
|oxidoreduction coenzyme metabolic process|
|cellular ketone metabolic process|
|polyol metabolic process|
|coenzyme biosynthetic process|
|isoprenoid metabolic process|
|cellular carbohydrate metabolic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|alcohol metabolic process|
|mitochondrial inner membrane|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|mitochondrion|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.87|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.7|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.591|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.572|
|[[:human genes:r:rpusd4|RPUSD4]]|0.57|
|[[:human genes:c:coa6|COA6]]|0.564|
|[[:human genes:m:mrps34|MRPS34]]|0.563|
|[[:human genes:c:c12orf65|C12orf65]]|0.561|
|[[:human genes:n:ndufa3|NDUFA3]]|0.561|
|[[:human genes:m:mrpl23|MRPL23]]|0.555|
|[[:human genes:m:mrpl21|MRPL21]]|0.551|
|[[:human genes:v:vars2|VARS2]]|0.549|
|[[:human genes:m:mrpl53|MRPL53]]|0.548|
|[[:human genes:c:coq3|COQ3]]|0.544|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.543|
|[[:human genes:n:ndufa2|NDUFA2]]|0.538|
|[[:human genes:s:selrc1|SELRC1]]|0.536|
|[[:human genes:s:sco2|SCO2]]|0.536|
|[[:human genes:p:pdss1|PDSS1]]|0.535|
|[[:human genes:m:mrpl47|MRPL47]]|0.534|
|[[:human genes:f:fastkd2|FASTKD2]]|0.532|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.531|
|[[:human genes:c:coq4|COQ4]]|0.53|
|[[:human genes:n:ndufc2|NDUFC2]]|0.529|
|[[:human genes:n:ndufb11|NDUFB11]]|0.528|
|[[:human genes:l:lrpprc|LRPPRC]]|0.525|
|[[:human genes:t:tars2|TARS2]]|0.523|
|[[:human genes:g:gfm1|GFM1]]|0.522|
|[[:human genes:m:mrps23|MRPS23]]|0.522|
|[[:human genes:m:mrps21|MRPS21]]|0.521|
|[[:human genes:g:gfm2|GFM2]]|0.517|
|[[:human genes:c:coq6|COQ6]]|0.515|
|[[:human genes:c:coq7|COQ7]]|0.515|
|[[:human genes:m:mrpl55|MRPL55]]|0.515|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.51|
|[[:human genes:m:mrp63|MRP63]]|0.51|
|[[:human genes:f:ftsj2|FTSJ2]]|0.509|
|[[:human genes:m:mtg2|MTG2]]|0.508|
|[[:human genes:a:acad9|ACAD9]]|0.508|
|[[:human genes:p:pet117|PET117]]|0.507|
|[[:human genes:d:dap3|DAP3]]|0.503|
|[[:human genes:e:ears2|EARS2]]|0.502|
|[[:human genes:m:mrps25|MRPS25]]|0.502|
|[[:human genes:m:mrps5|MRPS5]]|0.501|
|[[:human genes:w:wbscr16|WBSCR16]]|0.501|
|[[:human genes:t:tefm|TEFM]]|0.5|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.5|
|[[:human genes:m:mrps14|MRPS14]]|0.499|
|[[:human genes:b:bcs1l|BCS1L]]|0.498|
|[[:human genes:p:pnpt1|PNPT1]]|0.498|
|[[:human genes:t:timm17a|TIMM17A]]|0.497|
|[[:human genes:s:sars2|SARS2]]|0.497|
|[[:human genes:y:yars2|YARS2]]|0.496|
|[[:human genes:f:fastkd5|FASTKD5]]|0.495|
|[[:human genes:l:lars2|LARS2]]|0.494|
|[[:human genes:n:ndufs7|NDUFS7]]|0.493|
|[[:human genes:m:mtif3|MTIF3]]|0.493|
|[[:human genes:p:pdss2|PDSS2]]|0.493|
|[[:human genes:u:uqcc1|UQCC1]]|0.491|
|[[:human genes:m:mrpl44|MRPL44]]|0.49|
|[[:human genes:q:qrsl1|QRSL1]]|0.49|
|[[:human genes:c:cox16|COX16]]|0.489|
|[[:human genes:m:mrpl15|MRPL15]]|0.489|
|[[:human genes:n:ndufb3|NDUFB3]]|0.489|
|[[:human genes:a:aars2|AARS2]]|0.488|
|[[:human genes:p:pars2|PARS2]]|0.488|
|[[:human genes:m:mrps10|MRPS10]]|0.487|
|[[:human genes:m:mrps16|MRPS16]]|0.487|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.484|
|[[:human genes:g:grsf1|GRSF1]]|0.484|
|[[:human genes:m:mrps6|MRPS6]]|0.484|
|[[:human genes:m:mto1|MTO1]]|0.484|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.483|
|[[:human genes:n:nars2|NARS2]]|0.482|
|[[:human genes:n:ndufs2|NDUFS2]]|0.48|
|[[:human genes:c:coq5|COQ5]]|0.48|
|[[:human genes:p:polg2|POLG2]]|0.479|
|[[:human genes:c:coa3|COA3]]|0.477|
|[[:human genes:t:timm8b|TIMM8B]]|0.476|
|[[:human genes:m:mrps18a|MRPS18A]]|0.474|
|[[:human genes:m:mrpl1|MRPL1]]|0.471|
|[[:human genes:c:cox11|COX11]]|0.47|
|[[:human genes:c:chchd1|CHCHD1]]|0.469|
|[[:human genes:m:mrpl12|MRPL12]]|0.468|
|[[:human genes:n:ndufb5|NDUFB5]]|0.468|
|[[:human genes:e:eral1|ERAL1]]|0.467|
|[[:human genes:m:mrps11|MRPS11]]|0.467|
|[[:human genes:t:tmem261|TMEM261]]|0.466|
|[[:human genes:m:mettl17|METTL17]]|0.466|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.464|
|[[:human genes:i:iba57|IBA57]]|0.464|
|[[:human genes:m:mtg1|MTG1]]|0.463|
|[[:human genes:n:ndufb9|NDUFB9]]|0.462|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.461|
|[[:human genes:m:mrpl45|MRPL45]]|0.461|
|[[:human genes:m:mrps24|MRPS24]]|0.46|
|[[:human genes:p:polg|POLG]]|0.46|
|[[:human genes:n:ndufv1|NDUFV1]]|0.459|
|[[:human genes:m:mrpl3|MRPL3]]|0.459|
|[[:human genes:n:nubpl|NUBPL]]|0.458|
|[[:human genes:c:cars2|CARS2]]|0.457|
|[[:human genes:c:cox6c|COX6C]]|0.456|
|[[:human genes:e:ecsit|ECSIT]]|0.456|
|[[:human genes:c:c17orf89|C17orf89]]|0.455|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.454|
|[[:human genes:s:slc25a26|SLC25A26]]|0.454|
|[[:human genes:p:pet112|PET112]]|0.454|
|[[:human genes:m:mrps9|MRPS9]]|0.453|
|[[:human genes:m:mrpl4|MRPL4]]|0.453|
|[[:human genes:m:mterfd2|MTERFD2]]|0.452|
|[[:human genes:n:ndufb2|NDUFB2]]|0.452|
|[[:human genes:m:mrps12|MRPS12]]|0.452|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.452|
|[[:human genes:r:rbfa|RBFA]]|0.451|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.451|
|[[:human genes:m:mrpl22|MRPL22]]|0.45|
|[[:human genes:d:ddx28|DDX28]]|0.45|
|[[:human genes:m:mcat|MCAT]]|0.448|
|[[:human genes:n:ndufa1|NDUFA1]]|0.447|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.446|
|[[:human genes:w:wars2|WARS2]]|0.446|
|[[:human genes:n:ndufa11|NDUFA11]]|0.446|
|[[:human genes:n:ndufc1|NDUFC1]]|0.444|
|[[:human genes:r:rpusd3|RPUSD3]]|0.444|
|[[:human genes:m:mrpl20|MRPL20]]|0.442|
|[[:human genes:m:mtpap|MTPAP]]|0.442|
|[[:human genes:t:tufm|TUFM]]|0.44|
|[[:human genes:p:pitrm1|PITRM1]]|0.44|
|[[:human genes:n:ndufb7|NDUFB7]]|0.439|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.438|
|[[:human genes:n:ndufs5|NDUFS5]]|0.438|
|[[:human genes:n:ndufs8|NDUFS8]]|0.437|
|[[:human genes:f:fars2|FARS2]]|0.436|
|[[:human genes:m:mipep|MIPEP]]|0.434|
|[[:human genes:n:ndufa8|NDUFA8]]|0.433|
|[[:human genes:m:mrps26|MRPS26]]|0.433|
|[[:human genes:f:fastkd1|FASTKD1]]|0.43|
|[[:human genes:i:ict1|ICT1]]|0.428|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.426|
|[[:human genes:m:mrps7|MRPS7]]|0.425|
|[[:human genes:n:ndufb6|NDUFB6]]|0.425|
|[[:human genes:m:mrpl13|MRPL13]]|0.424|
|[[:human genes:c:c10orf2|C10orf2]]|0.421|
|[[:human genes:t:tomm20|TOMM20]]|0.42|
|[[:human genes:m:mtif2|MTIF2]]|0.419|
|[[:human genes:g:glrx5|GLRX5]]|0.418|
|[[:human genes:u:uqcc2|UQCC2]]|0.418|
|[[:human genes:c:cox15|COX15]]|0.417|
|[[:human genes:r:rars2|RARS2]]|0.417|
|[[:human genes:d:dhx30|DHX30]]|0.415|
|[[:human genes:m:mrpl43|MRPL43]]|0.413|
|[[:human genes:m:mars2|MARS2]]|0.413|
|[[:human genes:g:gatc|GATC]]|0.413|
|[[:human genes:c:cox6b1|COX6B1]]|0.411|
|[[:human genes:m:mrpl39|MRPL39]]|0.409|
|[[:human genes:t:trub2|TRUB2]]|0.409|
|[[:human genes:m:mrps27|MRPS27]]|0.407|
|[[:human genes:m:mrpl18|MRPL18]]|0.407|
|[[:human genes:m:malsu1|MALSU1]]|0.405|
|[[:human genes:s:ssbp1|SSBP1]]|0.404|
|[[:human genes:d:dars2|DARS2]]|0.404|
|[[:human genes:h:hars2|HARS2]]|0.402|
|[[:human genes:a:atp5sl|ATP5SL]]|0.402|
|[[:human genes:r:rmnd1|RMND1]]|0.401|
|[[:human genes:p:ptcd3|PTCD3]]|0.401|
|[[:human genes:m:mrps22|MRPS22]]|0.4|
|[[:human genes:f:foxred1|FOXRED1]]|0.4|
|[[:human genes:m:mterfd1|MTERFD1]]|0.4|
|[[:human genes:t:tomm22|TOMM22]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1978
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COQ2 Expression in NALM6 Cells: 3.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>