COX19 [The Human Chemical-Genetic Interaction Map Project]

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======= COX19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX19
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase assembly factor COX19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90639|90639]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q49B96|Q49B96]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610429|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be required for the assembly of mitochondrial cytochrome c oxidase. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CHCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular copper ion homeostasis|
|copper ion homeostasis|
|mitochondrial respiratory chain complex IV assembly|
|respiratory chain complex IV assembly|
|cytochrome complex assembly|
|mitochondrial intermembrane space|
|mitochondrial respiratory chain complex assembly|
|cellular transition metal ion homeostasis|
|transition metal ion homeostasis|
|mitochondrion organization|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular protein-containing complex assembly|
|cellular homeostasis|
|chemical homeostasis|
|mitochondrion|
|protein-containing complex assembly|
|homeostatic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.74|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.79|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.03|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.58|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl45|MRPL45]]|0.544|
|[[:human genes:l:lars2|LARS2]]|0.484|
|[[:human genes:n:nars2|NARS2]]|0.484|
|[[:human genes:p:pet117|PET117]]|0.47|
|[[:human genes:d:dap3|DAP3]]|0.461|
|[[:human genes:r:rars2|RARS2]]|0.453|
|[[:human genes:m:mrps26|MRPS26]]|0.453|
|[[:human genes:m:mrps21|MRPS21]]|0.452|
|[[:human genes:p:pet112|PET112]]|0.446|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.444|
|[[:human genes:g:gfm2|GFM2]]|0.443|
|[[:human genes:m:mrps5|MRPS5]]|0.44|
|[[:human genes:d:dars2|DARS2]]|0.438|
|[[:human genes:c:coa3|COA3]]|0.437|
|[[:human genes:m:mrp63|MRP63]]|0.436|
|[[:human genes:m:mrpl21|MRPL21]]|0.435|
|[[:human genes:f:fastkd5|FASTKD5]]|0.435|
|[[:human genes:c:coa6|COA6]]|0.435|
|[[:human genes:r:rbfa|RBFA]]|0.435|
|[[:human genes:y:yars2|YARS2]]|0.434|
|[[:human genes:m:mtif2|MTIF2]]|0.434|
|[[:human genes:p:pars2|PARS2]]|0.433|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.432|
|[[:human genes:m:mrpl42|MRPL42]]|0.432|
|[[:human genes:m:mrpl20|MRPL20]]|0.43|
|[[:human genes:m:mrpl47|MRPL47]]|0.429|
|[[:human genes:m:mrps16|MRPS16]]|0.425|
|[[:human genes:s:sco1|SCO1]]|0.423|
|[[:human genes:m:mrpl43|MRPL43]]|0.421|
|[[:human genes:m:mrpl23|MRPL23]]|0.421|
|[[:human genes:n:ndufa1|NDUFA1]]|0.419|
|[[:human genes:t:tfb1m|TFB1M]]|0.418|
|[[:human genes:e:ears2|EARS2]]|0.418|
|[[:human genes:s:selrc1|SELRC1]]|0.417|
|[[:human genes:q:qrsl1|QRSL1]]|0.416|
|[[:human genes:m:mrps14|MRPS14]]|0.415|
|[[:human genes:m:mrps34|MRPS34]]|0.415|
|[[:human genes:m:mrps25|MRPS25]]|0.414|
|[[:human genes:m:mettl17|METTL17]]|0.41|
|[[:human genes:m:mrps33|MRPS33]]|0.407|
|[[:human genes:c:cox11|COX11]]|0.407|
|[[:human genes:m:mrpl53|MRPL53]]|0.404|
|[[:human genes:h:hars2|HARS2]]|0.404|
|[[:human genes:r:rpusd3|RPUSD3]]|0.404|
|[[:human genes:m:mrpl49|MRPL49]]|0.401|
|[[:human genes:n:ndufc2|NDUFC2]]|0.4|
|[[:human genes:m:mars2|MARS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4188
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX19 Expression in NALM6 Cells: 4.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>