COX20 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= COX20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX20
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase assembly factor COX20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116228|116228]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5RI15|Q5RI15]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614698|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that plays a role in the assembly of cytochrome C oxidase, an important component of the respiratory pathway. It contains two transmembrane helices and localizes to the mitochondrial membrane. Mutations in this gene can cause mitochondrial complex IV deficiency, which results in ataxia and muscle hypotonia. There are multiple pseudogenes for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:23125284). Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme (PubMed:24403053). {ECO:0000269|PubMed:23125284, ECO:0000269|PubMed:24403053}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3767|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex IV assembly|
|respiratory chain complex IV assembly|
|cytochrome complex assembly|
|mitochondrial respiratory chain complex assembly|
|mitochondrial inner membrane|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|mitochondrion|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.94|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.99|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nars2|NARS2]]|0.561|
|[[:human genes:e:ears2|EARS2]]|0.554|
|[[:human genes:p:pet112|PET112]]|0.547|
|[[:human genes:p:pet117|PET117]]|0.54|
|[[:human genes:s:selrc1|SELRC1]]|0.527|
|[[:human genes:s:sco2|SCO2]]|0.52|
|[[:human genes:r:rars2|RARS2]]|0.509|
|[[:human genes:l:lars2|LARS2]]|0.506|
|[[:human genes:c:coa6|COA6]]|0.503|
|[[:human genes:a:aars2|AARS2]]|0.501|
|[[:human genes:t:tfb1m|TFB1M]]|0.487|
|[[:human genes:q:qrsl1|QRSL1]]|0.484|
|[[:human genes:t:tars2|TARS2]]|0.483|
|[[:human genes:d:dap3|DAP3]]|0.482|
|[[:human genes:y:yars2|YARS2]]|0.48|
|[[:human genes:c:cox11|COX11]]|0.476|
|[[:human genes:m:mtif2|MTIF2]]|0.47|
|[[:human genes:m:mrpl21|MRPL21]]|0.462|
|[[:human genes:p:pars2|PARS2]]|0.462|
|[[:human genes:m:mrps16|MRPS16]]|0.461|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.455|
|[[:human genes:c:coa3|COA3]]|0.452|
|[[:human genes:w:wars2|WARS2]]|0.45|
|[[:human genes:g:gfm1|GFM1]]|0.449|
|[[:human genes:f:fastkd5|FASTKD5]]|0.448|
|[[:human genes:m:mrps21|MRPS21]]|0.446|
|[[:human genes:t:tefm|TEFM]]|0.443|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.442|
|[[:human genes:c:cox15|COX15]]|0.442|
|[[:human genes:m:mrpl45|MRPL45]]|0.442|
|[[:human genes:h:hars2|HARS2]]|0.44|
|[[:human genes:c:clpp|CLPP]]|0.438|
|[[:human genes:m:mrps12|MRPS12]]|0.438|
|[[:human genes:c:cox16|COX16]]|0.437|
|[[:human genes:m:mrps6|MRPS6]]|0.436|
|[[:human genes:m:mrps25|MRPS25]]|0.434|
|[[:human genes:m:mrpl53|MRPL53]]|0.428|
|[[:human genes:d:ddx28|DDX28]]|0.426|
|[[:human genes:n:ndufc2|NDUFC2]]|0.426|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.422|
|[[:human genes:m:mrpl47|MRPL47]]|0.422|
|[[:human genes:m:mettl17|METTL17]]|0.421|
|[[:human genes:d:dars2|DARS2]]|0.42|
|[[:human genes:m:mrps34|MRPS34]]|0.419|
|[[:human genes:c:cox7b|COX7B]]|0.416|
|[[:human genes:m:malsu1|MALSU1]]|0.415|
|[[:human genes:m:mrps26|MRPS26]]|0.414|
|[[:human genes:n:ndufa10|NDUFA10]]|0.413|
|[[:human genes:c:cars2|CARS2]]|0.413|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.412|
|[[:human genes:w:wbscr16|WBSCR16]]|0.409|
|[[:human genes:b:bcs1l|BCS1L]]|0.408|
|[[:human genes:m:mrps27|MRPS27]]|0.408|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.406|
|[[:human genes:v:vars2|VARS2]]|0.406|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.404|
|[[:human genes:m:mrp63|MRP63]]|0.402|
|[[:human genes:c:c10orf2|C10orf2]]|0.401|
|[[:human genes:f:ftsj2|FTSJ2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2133
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX20 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>