COX4I1 [The Human Chemical-Genetic Interaction Map Project]

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======= COX4I1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX4I1
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase subunit 4I1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1327|1327]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13073|P13073]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX4I1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX4I1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123864|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COX4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex IV|
|aerobic electron transport chain|
|mitochondrial electron transport, cytochrome c to oxygen|
|cytochrome-c oxidase activity|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|proton transmembrane transport|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|response to nutrient|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|response to nutrient levels|
|response to extracellular stimulus|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|ion transmembrane transport|
|oxidation-reduction process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|ion transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.01|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.86|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.73|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.83|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.92|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.95|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.97|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.444|
|[[:human genes:c:cox11|COX11]]|0.429|
|[[:human genes:t:tars2|TARS2]]|0.42|
|[[:human genes:m:mrps35|MRPS35]]|0.41|
|[[:human genes:s:sco2|SCO2]]|0.409|
|[[:human genes:a:aars2|AARS2]]|0.407|
|[[:human genes:f:fars2|FARS2]]|0.406|
|[[:human genes:c:coa3|COA3]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1786
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX4I1 Expression in NALM6 Cells: 7.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>