COX6B1 [The Human Chemical-Genetic Interaction Map Project]

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======= COX6B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX6B1
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase subunit 6B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1340|1340]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14854|P14854]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX6B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX6B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/124089|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Connects the two COX monomers into the physiological dimeric form. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COX6B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|respiratory chain complex IV|
|aerobic electron transport chain|
|mitochondrial electron transport, cytochrome c to oxygen|
|cytochrome-c oxidase activity|
|substantia nigra development|
|neural nucleus development|
|mitochondrial intermembrane space|
|aerobic respiration|
|midbrain development|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|proton transmembrane transport|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|brain development|
|head development|
|cation transport|
|ion transmembrane transport|
|oxidation-reduction process|
|central nervous system development|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.93|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.71|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.71|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.72|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.73|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.75|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.75|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.78|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.78|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.81|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.84|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.86|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.95|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.02|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.23|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl47|MRPL47]]|0.568|
|[[:human genes:c:cox16|COX16]]|0.525|
|[[:human genes:m:mrpl23|MRPL23]]|0.515|
|[[:human genes:c:coa3|COA3]]|0.509|
|[[:human genes:m:mrpl21|MRPL21]]|0.507|
|[[:human genes:p:pet117|PET117]]|0.501|
|[[:human genes:c:coa5|COA5]]|0.496|
|[[:human genes:m:mtpap|MTPAP]]|0.495|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.494|
|[[:human genes:m:mrps26|MRPS26]]|0.494|
|[[:human genes:s:selrc1|SELRC1]]|0.494|
|[[:human genes:t:trub2|TRUB2]]|0.494|
|[[:human genes:m:mrps34|MRPS34]]|0.492|
|[[:human genes:m:mrps9|MRPS9]]|0.491|
|[[:human genes:c:cox7c|COX7C]]|0.491|
|[[:human genes:c:coa6|COA6]]|0.489|
|[[:human genes:f:fars2|FARS2]]|0.488|
|[[:human genes:m:mrp63|MRP63]]|0.485|
|[[:human genes:f:fastkd5|FASTKD5]]|0.484|
|[[:human genes:m:mrps21|MRPS21]]|0.482|
|[[:human genes:q:qrsl1|QRSL1]]|0.477|
|[[:human genes:c:chchd1|CHCHD1]]|0.472|
|[[:human genes:c:cox7b|COX7B]]|0.47|
|[[:human genes:s:sco2|SCO2]]|0.468|
|[[:human genes:c:cox17|COX17]]|0.468|
|[[:human genes:m:mrps6|MRPS6]]|0.467|
|[[:human genes:m:mrps5|MRPS5]]|0.465|
|[[:human genes:m:mrps12|MRPS12]]|0.464|
|[[:human genes:s:sars2|SARS2]]|0.464|
|[[:human genes:d:dap3|DAP3]]|0.462|
|[[:human genes:m:mrps25|MRPS25]]|0.462|
|[[:human genes:m:mrps2|MRPS2]]|0.461|
|[[:human genes:d:dars2|DARS2]]|0.46|
|[[:human genes:m:mrpl18|MRPL18]]|0.459|
|[[:human genes:r:rars2|RARS2]]|0.456|
|[[:human genes:c:cox11|COX11]]|0.456|
|[[:human genes:n:ndufa3|NDUFA3]]|0.45|
|[[:human genes:y:yars2|YARS2]]|0.448|
|[[:human genes:c:coq4|COQ4]]|0.448|
|[[:human genes:m:mrps14|MRPS14]]|0.444|
|[[:human genes:v:vars2|VARS2]]|0.443|
|[[:human genes:p:polrmt|POLRMT]]|0.442|
|[[:human genes:m:mrps35|MRPS35]]|0.442|
|[[:human genes:m:mrpl3|MRPL3]]|0.441|
|[[:human genes:p:pdss1|PDSS1]]|0.437|
|[[:human genes:c:cox5b|COX5B]]|0.436|
|[[:human genes:m:mrps18a|MRPS18A]]|0.435|
|[[:human genes:m:mrpl55|MRPL55]]|0.434|
|[[:human genes:n:nars2|NARS2]]|0.433|
|[[:human genes:n:ndufv1|NDUFV1]]|0.428|
|[[:human genes:m:mrps16|MRPS16]]|0.428|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.427|
|[[:human genes:m:mrpl27|MRPL27]]|0.427|
|[[:human genes:b:bcs1l|BCS1L]]|0.427|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.427|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.426|
|[[:human genes:s:slc31a1|SLC31A1]]|0.425|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.425|
|[[:human genes:c:cox10|COX10]]|0.42|
|[[:human genes:t:tfam|TFAM]]|0.42|
|[[:human genes:m:mrpl33|MRPL33]]|0.42|
|[[:human genes:l:lrpprc|LRPPRC]]|0.419|
|[[:human genes:m:mrpl52|MRPL52]]|0.419|
|[[:human genes:m:mrps24|MRPS24]]|0.419|
|[[:human genes:r:rpusd4|RPUSD4]]|0.418|
|[[:human genes:m:mtg2|MTG2]]|0.417|
|[[:human genes:m:mrpl43|MRPL43]]|0.415|
|[[:human genes:e:ears2|EARS2]]|0.415|
|[[:human genes:p:pars2|PARS2]]|0.414|
|[[:human genes:h:higd2a|HIGD2A]]|0.413|
|[[:human genes:n:ndufa5|NDUFA5]]|0.413|
|[[:human genes:a:aars2|AARS2]]|0.413|
|[[:human genes:c:cox15|COX15]]|0.413|
|[[:human genes:c:coq2|COQ2]]|0.411|
|[[:human genes:m:mrpl53|MRPL53]]|0.408|
|[[:human genes:n:ndufa1|NDUFA1]]|0.408|
|[[:human genes:n:ndufc2|NDUFC2]]|0.408|
|[[:human genes:m:mettl17|METTL17]]|0.408|
|[[:human genes:h:hars2|HARS2]]|0.407|
|[[:human genes:n:ndufb6|NDUFB6]]|0.407|
|[[:human genes:c:cars2|CARS2]]|0.407|
|[[:human genes:p:ptcd3|PTCD3]]|0.406|
|[[:human genes:m:mrpl45|MRPL45]]|0.404|
|[[:human genes:u:uqcrq|UQCRQ]]|0.403|
|[[:human genes:u:uqcrfs1|UQCRFS1]]|0.402|
|[[:human genes:n:ndufb11|NDUFB11]]|0.401|
|[[:human genes:t:tufm|TUFM]]|0.401|
|[[:human genes:c:c12orf65|C12orf65]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 168
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX6B1 Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>