COX7C [The Human Chemical-Genetic Interaction Map Project]

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======= COX7C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX7C
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase subunit 7C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1350|1350]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15954|P15954]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX7C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX7C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603774|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COX7C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial electron transport, cytochrome c to oxygen|
|aerobic electron transport chain|
|cytochrome-c oxidase activity|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|proton transmembrane transport|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|ion transmembrane transport|
|oxidation-reduction process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cox6b1|COX6B1]]|0.491|
|[[:human genes:c:cox16|COX16]]|0.471|
|[[:human genes:m:mrps26|MRPS26]]|0.454|
|[[:human genes:s:sars2|SARS2]]|0.449|
|[[:human genes:m:mrps12|MRPS12]]|0.434|
|[[:human genes:m:mrpl45|MRPL45]]|0.423|
|[[:human genes:m:mrps21|MRPS21]]|0.419|
|[[:human genes:s:selrc1|SELRC1]]|0.415|
|[[:human genes:c:coa6|COA6]]|0.413|
|[[:human genes:p:pet117|PET117]]|0.407|
|[[:human genes:v:vars2|VARS2]]|0.406|
|[[:human genes:c:cox7b|COX7B]]|0.406|
|[[:human genes:s:sco2|SCO2]]|0.404|
|[[:human genes:c:cox17|COX17]]|0.404|
|[[:human genes:m:mrpl21|MRPL21]]|0.403|
|[[:human genes:m:mrpl47|MRPL47]]|0.402|
|[[:human genes:c:cox11|COX11]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 226/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|15/28|
|bone|7/26|
|breast|12/33|
|central nervous system|8/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|3/21|
|liver|10/20|
|lung|33/75|
|lymphocyte|7/16|
|ovary|4/26|
|pancreas|4/24|
|peripheral nervous system|7/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1630
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX7C Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>