CPEB2 [The Human Chemical-Genetic Interaction Map Project]

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======= CPEB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPEB2
  * **<color #00a2e8>Official Name</color>**: cytoplasmic polyadenylation element binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=132864|132864]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z5Q1|Q7Z5Q1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPEB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPEB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610605|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0, ECO:0000269|PubMed:26398195}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cytoplasmic translational elongation|
|negative regulation of translational elongation|
|negative regulation of cytoplasmic translation|
|messenger ribonucleoprotein complex|
|regulation of cytoplasmic translational elongation|
|ribosomal large subunit binding|
|GTPase inhibitor activity|
|translation repressor activity, mRNA regulatory element binding|
|ribosomal small subunit binding|
|cellular response to arsenic-containing substance|
|regulation of translational elongation|
|translation factor activity, RNA binding|
|mRNA 3-UTR AU-rich region binding|
|regulation of cytoplasmic translation|
|response to arsenic-containing substance|
|negative regulation of GTPase activity|
|ribosome binding|
|mRNA 3-UTR binding|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|cellular response to insulin stimulus|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|cellular response to oxygen levels|
|response to insulin|
|cellular response to oxidative stress|
|cellular response to peptide hormone stimulus|
|synapse|
|neuron projection|
|cellular response to peptide|
|response to hypoxia|
|regulation of translation|
|response to decreased oxygen levels|
|response to oxygen levels|
|translation|
|response to oxidative stress|
|response to peptide hormone|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|negative regulation of hydrolase activity|
|response to peptide|
|regulation of GTPase activity|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|response to hormone|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.72|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.73|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.82|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.82|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.85|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.95|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.04|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|2.37|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3351
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPEB2 Expression in NALM6 Cells: 2.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>