CPSF3L [The Human Chemical-Genetic Interaction Map Project]

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======= CPSF3L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTS11
  * **<color #00a2e8>Official Name</color>**: integrator complex subunit 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54973|54973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TA45|Q5TA45]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPSF3L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPSF3L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611354|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lactamase B 2|
|Lactamase B|
|Beta-Casp|
|RMMBL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrator complex|
|snRNA processing|
|snRNA metabolic process|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|hydrolase activity|
|ncRNA transcription|
|blood microparticle|
|ncRNA processing|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.17|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.96|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.93|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.93|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.84|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.84|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.7|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.73|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 964
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPSF3L Expression in NALM6 Cells: 6.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>