CR1 [The Human Chemical-Genetic Interaction Map Project]

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======= CR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CR1
  * **<color #00a2e8>Official Name</color>**: complement C3b/C4b receptor 1 (Knops blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1378|1378]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17927|P17927]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120620|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates cellular binding of particles and immune complexes that have activated complement.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|complement component C3b receptor activity|
|complement component C4b receptor activity|
|negative regulation of complement activation, alternative pathway|
|regulation of complement activation, alternative pathway|
|complement component C4b binding|
|positive regulation of serine-type endopeptidase activity|
|positive regulation of serine-type peptidase activity|
|negative regulation of complement activation, classical pathway|
|regulation of complement activation, classical pathway|
|complement component C3b binding|
|negative regulation of humoral immune response mediated by circulating immunoglobulin|
|negative regulation of serine-type endopeptidase activity|
|negative regulation of serine-type peptidase activity|
|negative regulation of complement activation|
|regulation of serine-type endopeptidase activity|
|regulation of serine-type peptidase activity|
|negative regulation of B cell mediated immunity|
|negative regulation of immunoglobulin mediated immune response|
|regulation of humoral immune response mediated by circulating immunoglobulin|
|negative regulation of humoral immune response|
|complement receptor mediated signaling pathway|
|regulation of regulatory T cell differentiation|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of adaptive immune response|
|negative regulation of leukocyte mediated immunity|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|negative regulation of innate immune response|
|ficolin-1-rich granule membrane|
|virus receptor activity|
|negative regulation of response to biotic stimulus|
|viral entry into host cell|
|secretory granule membrane|
|entry into host cell|
|entry into host|
|regulation of complement activation|
|negative regulation of immune effector process|
|regulation of humoral immune response|
|regulation of T cell differentiation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|interaction with host|
|regulation of adaptive immune response|
|complement activation, classical pathway|
|regulation of lymphocyte differentiation|
|humoral immune response mediated by circulating immunoglobulin|
|positive regulation of endopeptidase activity|
|complement activation|
|positive regulation of peptidase activity|
|viral life cycle|
|regulation of leukocyte mediated immunity|
|immunoglobulin mediated immune response|
|negative regulation of defense response|
|B cell mediated immunity|
|negative regulation of multi-organism process|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|lymphocyte mediated immunity|
|regulation of leukocyte differentiation|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of T cell activation|
|humoral immune response|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|negative regulation of response to external stimulus|
|regulation of endopeptidase activity|
|negative regulation of immune system process|
|regulation of peptidase activity|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|adaptive immune response|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|viral process|
|regulated exocytosis|
|regulation of proteolysis|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|negative regulation of catalytic activity|
|exocytosis|
|interspecies interaction between organisms|
|positive regulation of immune response|
|leukocyte activation|
|defense response to other organism|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of response to stress|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14537
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CR1 Expression in NALM6 Cells: 1.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>