CRADD [The Human Chemical-Genetic Interaction Map Project]

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======= CRADD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRADD
  * **<color #00a2e8>Official Name</color>**: CASP2 and RIPK1 domain containing adaptor with death domain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8738|8738]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78560|P78560]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRADD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRADD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603454|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Death|
|CARD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|death domain binding|
|extrinsic apoptotic signaling pathway via death domain receptors|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|DNA damage response, signal transduction by p53 class mediator|
|cellular response to mechanical stimulus|
|protein binding, bridging|
|positive regulation of cell cycle arrest|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitotic DNA damage checkpoint|
|extrinsic apoptotic signaling pathway|
|protease binding|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|signal transduction by p53 class mediator|
|DNA damage checkpoint|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cysteine-type endopeptidase activity|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|positive regulation of peptidase activity|
|cell cycle checkpoint|
|response to mechanical stimulus|
|negative regulation of mitotic cell cycle phase transition|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cell cycle phase transition|
|regulation of cysteine-type endopeptidase activity|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|negative regulation of cell cycle process|
|cellular response to external stimulus|
|positive regulation of proteolysis|
|positive regulation of cell cycle|
|regulation of apoptotic signaling pathway|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|mitotic cell cycle|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|apoptotic process|
|cell cycle process|
|programmed cell death|
|cell death|
|response to abiotic stimulus|
|regulation of cell cycle|
|regulation of hydrolase activity|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.59|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|4.98|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|5.52|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|6.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c2cd3|C2CD3]]|0.763|
|[[:human genes:p:pidd|PIDD]]|0.758|
|[[:human genes:c:casp2|CASP2]]|0.757|
|[[:human genes:o:odf2|ODF2]]|0.742|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.732|
|[[:human genes:o:ofd1|OFD1]]|0.709|
|[[:human genes:c:cep128|CEP128]]|0.669|
|[[:human genes:p:pibf1|PIBF1]]|0.668|
|[[:human genes:a:ankrd26|ANKRD26]]|0.662|
|[[:human genes:n:nin|NIN]]|0.656|
|[[:human genes:s:sclt1|SCLT1]]|0.64|
|[[:human genes:c:ccdc41|CCDC41]]|0.636|
|[[:human genes:c:cep76|CEP76]]|0.636|
|[[:human genes:c:cep120|CEP120]]|0.628|
|[[:human genes:c:c16orf59|C16orf59]]|0.624|
|[[:human genes:c:c14orf80|C14orf80]]|0.594|
|[[:human genes:f:fopnl|FOPNL]]|0.587|
|[[:human genes:c:cep78|CEP78]]|0.563|
|[[:human genes:h:hyls1|HYLS1]]|0.538|
|[[:human genes:t:tubd1|TUBD1]]|0.518|
|[[:human genes:t:tube1|TUBE1]]|0.502|
|[[:human genes:p:ppp1r35|PPP1R35]]|0.48|
|[[:human genes:r:rttn|RTTN]]|0.479|
|[[:human genes:c:cep44|CEP44]]|0.464|
|[[:human genes:k:kiaa0586|KIAA0586]]|0.448|
|[[:human genes:c:cenpj|CENPJ]]|0.437|
|[[:human genes:i:ipp|IPP]]|0.425|
|[[:human genes:c:cep152|CEP152]]|0.423|
|[[:human genes:w:wbp11|WBP11]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17195
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRADD Expression in NALM6 Cells: 3.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>