CS [The Human Chemical-Genetic Interaction Map Project]

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======= CS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CS
  * **<color #00a2e8>Official Name</color>**: citrate synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1431|1431]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75390|O75390]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118950|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Citrate synt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|citrate (Si)-synthase activity|
|citrate metabolic process|
|tricarboxylic acid metabolic process|
|tricarboxylic acid cycle|
|aerobic respiration|
|antibiotic metabolic process|
|cellular respiration|
|energy derivation by oxidation of organic compounds|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|drug metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|RNA binding|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.05|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.92|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.86|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.72|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.74|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.75|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.01|
|[[:results:exp274|Citral 50μM R06 exp274]]|4.11|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|6.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.543|
|[[:human genes:p:pdha1|PDHA1]]|0.521|
|[[:human genes:d:dlat|DLAT]]|0.466|
|[[:human genes:p:pdhb|PDHB]]|0.442|
|[[:human genes:m:mpc1|MPC1]]|0.429|
|[[:human genes:p:pdhx|PDHX]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4824
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CS Expression in NALM6 Cells: 8.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>