CSE1L [The Human Chemical-Genetic Interaction Map Project]

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======= CSE1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSE1L
  * **<color #00a2e8>Official Name</color>**: chromosome segregation 1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1434|1434]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55060|P55060]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSE1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSE1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601342|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cse1|
|CAS CSE1|
|IBN N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear export signal receptor activity|
|Ran GTPase binding|
|protein import into nucleus|
|import into nucleus|
|protein import|
|protein export from nucleus|
|nuclear export|
|protein localization to nucleus|
|nuclear envelope|
|nucleocytoplasmic transport|
|nuclear transport|
|establishment of protein localization to organelle|
|protein localization to organelle|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.42|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.09|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.82|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.73|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.73|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.74|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.74|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.84|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|2.1|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 680/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|26/28|
|bone|25/26|
|breast|31/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|20/21|
|liver|16/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|20/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|24/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 105
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSE1L Expression in NALM6 Cells: 8.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>