CSF3R [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CSF3R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSF3R
  * **<color #00a2e8>Official Name</color>**: colony stimulating factor 3 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1441|1441]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99062|Q99062]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSF3R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSF3R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138971|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. {ECO:0000269|PubMed:7514305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lep receptor Ig|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|granulocyte colony-stimulating factor binding|
|interleukin-3 binding|
|interleukin-3 receptor activity|
|interleukin-3-mediated signaling pathway|
|response to interleukin-3|
|cellular response to interleukin-3|
|amelogenesis|
|cytokine binding|
|cytokine receptor activity|
|odontogenesis of dentin-containing tooth|
|neutrophil chemotaxis|
|granulocyte chemotaxis|
|neutrophil migration|
|granulocyte migration|
|odontogenesis|
|myeloid leukocyte migration|
|leukocyte chemotaxis|
|signaling receptor activity|
|receptor complex|
|cell chemotaxis|
|regulation of myeloid cell differentiation|
|leukocyte migration|
|external side of plasma membrane|
|regulation of hemopoiesis|
|chemotaxis|
|taxis|
|cytokine-mediated signaling pathway|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|cellular response to cytokine stimulus|
|cell motility|
|localization of cell|
|response to cytokine|
|locomotion|
|defense response|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|regulation of immune system process|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8429
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSF3R Expression in NALM6 Cells: 1.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>