CSNK1E [The Human Chemical-Genetic Interaction Map Project]

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======= CSNK1E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSNK1E
  * **<color #00a2e8>Official Name</color>**: casein kinase 1 epsilon
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1454|1454]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49674|P49674]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSNK1E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSNK1E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600863|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. {ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation|
|regulation of Wnt-mediated midbrain dopaminergic neuron differentiation|
|positive regulation of midbrain dopaminergic neuron differentiation|
|positive regulation of dopaminergic neuron differentiation|
|regulation of midbrain dopaminergic neuron differentiation|
|regulation of dopaminergic neuron differentiation|
|positive regulation of non-canonical Wnt signaling pathway|
|regulation of non-canonical Wnt signaling pathway|
|circadian regulation of gene expression|
|peptidyl-threonine phosphorylation|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|canonical Wnt signaling pathway|
|peptidyl-threonine modification|
|ciliary basal body-plasma membrane docking|
|positive regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of protein binding|
|positive regulation of proteasomal protein catabolic process|
|regulation of circadian rhythm|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|positive regulation of cellular protein catabolic process|
|circadian rhythm|
|positive regulation of canonical Wnt signaling pathway|
|regulation of ubiquitin-dependent protein catabolic process|
|organelle localization by membrane tethering|
|negative regulation of binding|
|peptidyl-serine phosphorylation|
|positive regulation of Wnt signaling pathway|
|membrane docking|
|regulation of proteasomal protein catabolic process|
|regulation of G2/M transition of mitotic cell cycle|
|peptidyl-serine modification|
|regulation of cell cycle G2/M phase transition|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein binding|
|protein kinase activity|
|regulation of cellular protein catabolic process|
|mitotic cell cycle phase transition|
|rhythmic process|
|cell cycle phase transition|
|regulation of canonical Wnt signaling pathway|
|cilium assembly|
|cell-cell signaling by wnt|
|positive regulation of proteolysis|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|cilium organization|
|positive regulation of neuron differentiation|
|regulation of binding|
|regulation of protein catabolic process|
|regulation of mitotic cell cycle phase transition|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|positive regulation of neurogenesis|
|DNA repair|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|endocytosis|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|import into cell|
|mitotic cell cycle|
|regulation of proteolysis|
|DNA metabolic process|
|regulation of cell cycle process|
|organelle assembly|
|cellular response to DNA damage stimulus|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of catabolic process|
|cell cycle process|
|regulation of protein localization|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|phosphorylation|
|cell cycle|
|positive regulation of developmental process|
|RNA binding|
|ATP binding|
|generation of neurons|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.84|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.84|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13145
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSNK1E Expression in NALM6 Cells: 6.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>