CSPG4 [The Human Chemical-Genetic Interaction Map Project]

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======= CSPG4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSPG4
  * **<color #00a2e8>Official Name</color>**: chondroitin sulfate proteoglycan 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1464|1464]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UVK1|Q6UVK1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSPG4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSPG4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601172|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin- mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. {ECO:0000269|PubMed:10587647, ECO:0000269|PubMed:11278606, ECO:0000269|PubMed:15210734}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin G 1|
|Laminin G 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dermatan sulfate biosynthetic process|
|dermatan sulfate metabolic process|
|chondroitin sulfate catabolic process|
|dermatan sulfate proteoglycan biosynthetic process|
|dermatan sulfate proteoglycan metabolic process|
|lamellipodium membrane|
|chondroitin sulfate biosynthetic process|
|chondroitin sulfate proteoglycan biosynthetic process|
|glial cell migration|
|chondroitin sulfate metabolic process|
|chondroitin sulfate proteoglycan metabolic process|
|sulfur compound catabolic process|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|proteoglycan biosynthetic process|
|proteoglycan metabolic process|
|lysosomal lumen|
|tissue remodeling|
|Golgi lumen|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|activation of MAPK activity|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|positive regulation of peptidyl-tyrosine phosphorylation|
|carbohydrate derivative catabolic process|
|gliogenesis|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of MAP kinase activity|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|angiogenesis|
|apical plasma membrane|
|glycoprotein biosynthetic process|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|collagen-containing extracellular matrix|
|sulfur compound metabolic process|
|glycoprotein metabolic process|
|blood vessel morphogenesis|
|focal adhesion|
|protein kinase binding|
|blood vessel development|
|drug metabolic process|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|monocarboxylic acid metabolic process|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|cell population proliferation|
|positive regulation of kinase activity|
|small molecule biosynthetic process|
|cell surface|
|carbohydrate derivative biosynthetic process|
|tube morphogenesis|
|positive regulation of transferase activity|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|tube development|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|cell migration|
|regulation of transferase activity|
|oxoacid metabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|localization of cell|
|cell motility|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|locomotion|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.73|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.74|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.79|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.81|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.85|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.04|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|2.08|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2483
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSPG4 Expression in NALM6 Cells: 3.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>