CSTF3 [The Human Chemical-Genetic Interaction Map Project]

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======= CSTF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSTF3
  * **<color #00a2e8>Official Name</color>**: cleavage stimulation factor subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1479|1479]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12996|Q12996]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSTF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSTF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600367|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Suf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA cleavage|
|mRNA polyadenylation|
|RNA polyadenylation|
|termination of RNA polymerase II transcription|
|DNA-templated transcription, termination|
|mRNA 3-end processing|
|RNA 3-end processing|
|RNA phosphodiester bond hydrolysis|
|mRNA binding|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|nucleic acid phosphodiester bond hydrolysis|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.71|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.73|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.74|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.76|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.84|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.85|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.88|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.89|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.05|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 324/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|14/28|
|blood|13/28|
|bone|18/25|
|breast|15/33|
|central nervous system|24/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|2/15|
|kidney|12/21|
|liver|8/20|
|lung|35/75|
|lymphocyte|10/14|
|ovary|15/26|
|pancreas|10/24|
|peripheral nervous system|10/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|2/7|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|15/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 591
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSTF3 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>