CTNNA1 [The Human Chemical-Genetic Interaction Map Project]

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======= CTNNA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTNNA1
  * **<color #00a2e8>Official Name</color>**: catenin alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1495|1495]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35221|P35221]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTNNA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTNNA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116805|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. {ECO:0000269|PubMed:25653389}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vinculin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of integrin-mediated signaling pathway|
|cellular response to indole-3-methanol|
|response to indole-3-methanol|
|negative regulation of neuroblast proliferation|
|gap junction assembly|
|zonula adherens|
|flotillin complex|
|vinculin binding|
|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|gamma-catenin binding|
|negative regulation of stem cell proliferation|
|regulation of integrin-mediated signaling pathway|
|epithelial cell-cell adhesion|
|negative regulation of neural precursor cell proliferation|
|axon regeneration|
|catenin complex|
|neuron projection regeneration|
|positive regulation of smoothened signaling pathway|
|regulation of neuroblast proliferation|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of signal transduction in absence of ligand|
|intercalated disc|
|apical junction assembly|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|positive regulation of extrinsic apoptotic signaling pathway|
|response to axon injury|
|ovarian follicle development|
|regulation of stem cell proliferation|
|response to estrogen|
|regulation of smoothened signaling pathway|
|odontogenesis of dentin-containing tooth|
|adherens junction organization|
|beta-catenin binding|
|cellular response to alcohol|
|positive regulation of muscle cell differentiation|
|acrosomal vesicle|
|regulation of neural precursor cell proliferation|
|female gonad development|
|development of primary female sexual characteristics|
|response to antineoplastic agent|
|negative regulation of extrinsic apoptotic signaling pathway|
|cell-cell junction assembly|
|female sex differentiation|
|protein heterooligomerization|
|odontogenesis|
|male gonad development|
|development of primary male sexual characteristics|
|cell-cell junction organization|
|regulation of muscle cell differentiation|
|regulation of extrinsic apoptotic signaling pathway|
|male sex differentiation|
|regeneration|
|cell junction assembly|
|cell-cell junction|
|positive regulation of apoptotic signaling pathway|
|lamellipodium|
|structural molecule activity|
|establishment or maintenance of cell polarity|
|actin filament binding|
|gonad development|
|cell junction organization|
|development of primary sexual characteristics|
|actin cytoskeleton|
|negative regulation of apoptotic signaling pathway|
|response to alcohol|
|sex differentiation|
|negative regulation of cell motility|
|aging|
|negative regulation of neurogenesis|
|negative regulation of cellular component movement|
|cadherin binding|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|negative regulation of cell development|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|axon development|
|focal adhesion|
|reproductive structure development|
|reproductive system development|
|protein heterodimerization activity|
|cell-cell adhesion|
|protein complex oligomerization|
|cellular response to organic cyclic compound|
|cell junction|
|response to wounding|
|cellular response to organonitrogen compound|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|neuron projection development|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|neuron development|
|regulation of neurogenesis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|negative regulation of cell death|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|RNA binding|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.71|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7318
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTNNA1 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>