CTSL [The Human Chemical-Genetic Interaction Map Project]

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======= CTSL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTSL
  * **<color #00a2e8>Official Name</color>**: cathepsin L
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1514|1514]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07711|P07711]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTSL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTSL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116880|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Important for the overall degradation of proteins in lysosomes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Inhibitor I29|
|Peptidase C1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|serpin family protein binding|
|macrophage apoptotic process|
|myeloid cell apoptotic process|
|endolysosome lumen|
|inflammatory cell apoptotic process|
|proteoglycan binding|
|cellular response to thyroid hormone stimulus|
|leukocyte apoptotic process|
|response to thyroid hormone|
|fibronectin binding|
|cysteine-type peptidase activity|
|multivesicular body|
|regulation of keratinocyte differentiation|
|collagen catabolic process|
|regulation of epidermal cell differentiation|
|collagen binding|
|collagen metabolic process|
|extracellular matrix disassembly|
|regulation of epidermis development|
|cysteine-type endopeptidase activity|
|lysosomal lumen|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|toll-like receptor signaling pathway|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|pattern recognition receptor signaling pathway|
|histone binding|
|regulation of epithelial cell differentiation|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|innate immune response-activating signal transduction|
|lysosome|
|activation of innate immune response|
|extracellular matrix organization|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|cellular component disassembly|
|regulation of innate immune response|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|adaptive immune response|
|cellular protein catabolic process|
|activation of immune response|
|protein catabolic process|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|response to hormone|
|apoptotic process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|cellular response to endogenous stimulus|
|proteolysis|
|response to endogenous stimulus|
|regulation of response to stress|
|extracellular space|
|regulation of immune system process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.93|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.85|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.74|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.76|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.42|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15229
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTSL Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>