CUL1 [The Human Chemical-Genetic Interaction Map Project]

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======= CUL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CUL1
  * **<color #00a2e8>Official Name</color>**: cullin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8454|8454]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13616|Q13616]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CUL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CUL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603134|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143, PubMed:25503564). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. {ECO:0000269|PubMed:15531760, ECO:0000269|PubMed:15640526, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:19679664, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23263282, ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:9663463}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cullin Nedd8|
|Cullin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Parkin-FBXW7-Cul1 ubiquitin ligase complex|
|SCF complex assembly|
|cullin-RING ubiquitin ligase complex|
|protein monoubiquitination|
|cellular iron ion homeostasis|
|SCF ubiquitin ligase complex|
|NIK/NF-kappaB signaling|
|iron ion homeostasis|
|negative regulation of G2/M transition of mitotic cell cycle|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|interleukin-1-mediated signaling pathway|
|negative regulation of cell cycle G2/M phase transition|
|stress-activated MAPK cascade|
|cellular transition metal ion homeostasis|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|G2/M transition of mitotic cell cycle|
|transition metal ion homeostasis|
|cell cycle G2/M phase transition|
|stress-activated protein kinase signaling cascade|
|intrinsic apoptotic signaling pathway|
|Fc-epsilon receptor signaling pathway|
|cellular response to interleukin-1|
|T cell receptor signaling pathway|
|regulation of G2/M transition of mitotic cell cycle|
|response to interleukin-1|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|Fc receptor signaling pathway|
|activation of innate immune response|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|antigen receptor-mediated signaling pathway|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|positive regulation of innate immune response|
|proteasomal protein catabolic process|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|post-translational protein modification|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cell population proliferation|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|mitotic cell cycle process|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|metal ion homeostasis|
|regulation of mitotic cell cycle|
|activation of immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|mitotic cell cycle|
|protein ubiquitination|
|viral process|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of cell cycle process|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|positive regulation of immune response|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|apoptotic process|
|animal organ morphogenesis|
|protein phosphorylation|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|cellular response to cytokine stimulus|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of cell cycle|
|proteolysis|
|phosphorylation|
|cell cycle|
|regulation of response to stress|
|protein-containing complex assembly|
|homeostatic process|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.43|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.31|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.9|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.85|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 514/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|25/28|
|bone|18/26|
|breast|25/33|
|central nervous system|34/56|
|cervix|2/4|
|colorectal|8/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|10/21|
|liver|12/20|
|lung|53/75|
|lymphocyte|10/16|
|ovary|21/26|
|pancreas|17/24|
|peripheral nervous system|13/16|
|plasma cell|12/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|7/9|
|thyroid|0/2|
|upper aerodigestive|16/22|
|urinary tract|19/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 895
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CUL1 Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>