CWC15 [The Human Chemical-Genetic Interaction Map Project]

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======= CWC15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CWC15
  * **<color #00a2e8>Official Name</color>**: CWC15 spliceosome associated protein homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51503|51503]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P013|Q9P013]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CWC15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CWC15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. {ECO:0000269|PubMed:20176811}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cwf Cwc 15|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type catalytic step 2 spliceosome|
|mRNA cis splicing, via spliceosome|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|mitochondrion|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.81|
|[[:results:exp539|42°C R08 exp539]]|-1.71|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.78|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.474|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.451|
|[[:human genes:c:ccdc94|CCDC94]]|0.436|
|[[:human genes:v:vps54|VPS54]]|0.432|
|[[:human genes:t:tfip11|TFIP11]]|0.431|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.428|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.423|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.422|
|[[:human genes:n:nol12|NOL12]]|0.415|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.408|
|[[:human genes:s:syt9|SYT9]]|0.402|
|[[:human genes:r:rpl10a|RPL10A]]|0.401|
|[[:human genes:m:mt1e|MT1E]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2200
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CWC15 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>