CXCL14 [The Human Chemical-Genetic Interaction Map Project]

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======= CXCL14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXCL14
  * **<color #00a2e8>Official Name</color>**: C-X-C motif chemokine ligand 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9547|9547]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95715|O95715]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXCL14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXCL14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604186|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. {ECO:0000269|PubMed:10049774, ECO:0000269|PubMed:10946286}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of natural killer cell chemotaxis|
|regulation of natural killer cell chemotaxis|
|positive regulation of lymphocyte chemotaxis|
|negative regulation of myoblast differentiation|
|regulation of lymphocyte chemotaxis|
|positive regulation of lymphocyte migration|
|chemokine activity|
|regulation of myoblast differentiation|
|regulation of lymphocyte migration|
|positive regulation of leukocyte chemotaxis|
|regulation of leukocyte chemotaxis|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|inner ear development|
|regulation of leukocyte migration|
|cell chemotaxis|
|regulation of chemotaxis|
|ear development|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|sensory organ development|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|positive regulation of response to external stimulus|
|negative regulation of cell differentiation|
|regulation of cell migration|
|regulation of cell motility|
|negative regulation of developmental process|
|cell migration|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|cell-cell signaling|
|positive regulation of immune system process|
|locomotion|
|movement of cell or subcellular component|
|extracellular space|
|regulation of immune system process|
|regulation of cell differentiation|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.84|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4217
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXCL14 Expression in NALM6 Cells: 2.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>