CXCL17 [The Human Chemical-Genetic Interaction Map Project]

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======= CXCL17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXCL17
  * **<color #00a2e8>Official Name</color>**: C-X-C motif chemokine ligand 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=284340|284340]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UXB2|Q6UXB2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXCL17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXCL17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611387|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203). {ECO:0000269|PubMed:16455961, ECO:0000269|PubMed:16989774, ECO:0000269|PubMed:17307946, ECO:0000269|PubMed:23115081, ECO:0000269|PubMed:25411203}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|macrophage chemotaxis|
|positive regulation of macrophage chemotaxis|
|positive regulation of monocyte chemotaxis|
|macrophage migration|
|positive regulation of macrophage migration|
|positive regulation of mononuclear cell migration|
|regulation of monocyte chemotaxis|
|regulation of macrophage chemotaxis|
|positive regulation of vascular endothelial growth factor production|
|regulation of vascular endothelial growth factor production|
|regulation of macrophage migration|
|regulation of granulocyte chemotaxis|
|regulation of mononuclear cell migration|
|positive regulation of leukocyte chemotaxis|
|regulation of leukocyte chemotaxis|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|negative regulation of inflammatory response|
|leukocyte chemotaxis|
|activation of MAPK activity|
|regulation of leukocyte migration|
|negative regulation of defense response|
|cell chemotaxis|
|regulation of chemotaxis|
|positive regulation of MAP kinase activity|
|angiogenesis|
|activation of protein kinase activity|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|negative regulation of response to external stimulus|
|leukocyte migration|
|blood vessel morphogenesis|
|positive regulation of cytokine production|
|blood vessel development|
|positive regulation of cell migration|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of cytokine production|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|locomotion|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.72|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9707
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXCL17 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>