CYFIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= CYFIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYFIP1
  * **<color #00a2e8>Official Name</color>**: cytoplasmic FMR1 interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23191|23191]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L576|Q7L576]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYFIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYFIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606322|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250|UniProtKB:Q7TMB8, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FragX IP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peripheral region of growth cone|
|negative regulation of synaptic vesicle recycling|
|regulation of translation at postsynapse, modulating synaptic transmission|
|regulation of translation at postsynapse|
|central region of growth cone|
|regulation of translation at synapse|
|regulation of modification of postsynaptic actin cytoskeleton|
|regulation of translation at synapse, modulating synaptic transmission|
|positive regulation of neurotrophin TRK receptor signaling pathway|
|regulation of modification of postsynaptic structure|
|positive regulation of Arp2/3 complex-mediated actin nucleation|
|SCAR complex|
|dendritic growth cone|
|dendrite extension|
|regulation of modification of synaptic structure|
|mRNA cap binding complex|
|RNA 7-methylguanosine cap binding|
|regulation of neurotrophin TRK receptor signaling pathway|
|modification of synaptic structure|
|positive regulation of ruffle assembly|
|positive regulation of actin nucleation|
|postsynaptic modulation of chemical synaptic transmission|
|regulation of Arp2/3 complex-mediated actin nucleation|
|filopodium tip|
|translation regulator activity|
|Rac protein signal transduction|
|ruffle organization|
|regulation of synaptic vesicle recycling|
|regulation of actin nucleation|
|axonal growth cone|
|regulation of ruffle assembly|
|excitatory synapse|
|lamellipodium assembly|
|axon extension|
|lamellipodium organization|
|positive regulation of axon extension|
|response to electrical stimulus|
|terminal bouton|
|Rac GTPase binding|
|tertiary granule lumen|
|neuron projection extension|
|specific granule lumen|
|vascular endothelial growth factor receptor signaling pathway|
|positive regulation of dendrite development|
|positive regulation of axonogenesis|
|developmental cell growth|
|cell growth|
|positive regulation of actin filament polymerization|
|ruffle|
|regulation of axon extension|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of extent of cell growth|
|regulation of synaptic vesicle cycle|
|developmental growth involved in morphogenesis|
|secretory granule lumen|
|positive regulation of protein polymerization|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|dendritic spine|
|regulation of dendrite development|
|regulation of cell shape|
|positive regulation of cell morphogenesis involved in differentiation|
|cellular response to insulin stimulus|
|positive regulation of cell growth|
|regulation of actin filament polymerization|
|positive regulation of developmental growth|
|lamellipodium|
|regulation of cell size|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of axonogenesis|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|actin filament binding|
|regulation of synapse organization|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|regulation of synapse structure or activity|
|response to insulin|
|Fc receptor signaling pathway|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|positive regulation of growth|
|axon guidance|
|regulation of actin filament organization|
|neuron projection guidance|
|cellular response to peptide hormone stimulus|
|synapse|
|synapse organization|
|regulation of cellular response to growth factor stimulus|
|positive regulation of neuron projection development|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|small GTPase mediated signal transduction|
|neuron projection|
|cellular response to peptide|
|regulation of developmental growth|
|phagocytosis|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of translation|
|positive regulation of neuron differentiation|
|neuronal cell body|
|axonogenesis|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|developmental growth|
|regulation of actin filament-based process|
|response to peptide hormone|
|growth|
|regulation of cellular amide metabolic process|
|axon development|
|focal adhesion|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|cell projection assembly|
|positive regulation of neurogenesis|
|response to peptide|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|neutrophil degranulation|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|neutrophil activation involved in immune response|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|leukocyte mediated immunity|
|exocytosis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|positive regulation of immune response|
|response to hormone|
|regulation of cellular localization|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|response to organonitrogen compound|
|secretion by cell|
|neuron differentiation|
|export from cell|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|plasma membrane bounded cell projection organization|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.88|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.75|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14774
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYFIP1 Expression in NALM6 Cells: 8.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>