CYFIP2 [The Human Chemical-Genetic Interaction Map Project]

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======= CYFIP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYFIP2
  * **<color #00a2e8>Official Name</color>**: cytoplasmic FMR1 interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26999|26999]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96F07|Q96F07]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYFIP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYFIP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606323|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:15048733, ECO:0000269|PubMed:17245118}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FragX IP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of neurotrophin TRK receptor signaling pathway|
|SCAR complex|
|dendrite extension|
|regulation of neurotrophin TRK receptor signaling pathway|
|RNA 7-methylguanosine cap binding|
|activation of cysteine-type endopeptidase activity|
|zymogen activation|
|neuron projection extension|
|vascular endothelial growth factor receptor signaling pathway|
|developmental cell growth|
|cell growth|
|developmental growth involved in morphogenesis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|positive regulation of cysteine-type endopeptidase activity|
|protein processing|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|protein maturation|
|regulation of cysteine-type endopeptidase activity|
|Fc receptor signaling pathway|
|axon guidance|
|neuron projection guidance|
|synapse|
|regulation of cellular response to growth factor stimulus|
|neuron projection|
|phagocytosis|
|positive regulation of proteolysis|
|axonogenesis|
|developmental growth|
|growth|
|axon development|
|regulation of endopeptidase activity|
|cell morphogenesis involved in neuron differentiation|
|regulation of peptidase activity|
|immune response-activating cell surface receptor signaling pathway|
|cell projection assembly|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|cell junction|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|activation of immune response|
|neuron projection development|
|perinuclear region of cytoplasm|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|neuron development|
|cellular component morphogenesis|
|positive regulation of immune response|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|neuron differentiation|
|programmed cell death|
|cell death|
|immune effector process|
|plasma membrane bounded cell projection organization|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|proteolysis|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of catalytic activity|
|generation of neurons|
|movement of cell or subcellular component|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|vesicle-mediated transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15174
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYFIP2 Expression in NALM6 Cells: 8.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>