DAXX [The Human Chemical-Genetic Interaction Map Project]

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======= DAXX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DAXX
  * **<color #00a2e8>Official Name</color>**: death domain associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1616|1616]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UER7|Q9UER7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DAXX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAXX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603186|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Daxx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to diamide|
|response to diamide|
|cellular response to sodium arsenite|
|response to sodium arsenite|
|cellular response to salt|
|SUMO binding|
|response to herbicide|
|response to insecticide|
|cellular response to arsenic-containing substance|
|response to salt|
|protein kinase activator activity|
|cellular response to copper ion|
|response to arsenic-containing substance|
|extrinsic apoptotic signaling pathway via death domain receptors|
|androgen receptor signaling pathway|
|cellular response to cadmium ion|
|activation of JUN kinase activity|
|androgen receptor binding|
|response to copper ion|
|chromosome, centromeric region|
|heat shock protein binding|
|response to cadmium ion|
|p53 binding|
|intracellular steroid hormone receptor signaling pathway|
|cellular response to heat|
|positive regulation of JUN kinase activity|
|JNK cascade|
|regulation of JUN kinase activity|
|positive regulation of neuron death|
|response to antineoplastic agent|
|extrinsic apoptotic signaling pathway|
|PML body|
|stress-activated MAPK cascade|
|protein N-terminus binding|
|response to heat|
|nucleosome assembly|
|cellular response to antibiotic|
|steroid hormone mediated signaling pathway|
|cellular response to unfolded protein|
|histone binding|
|chromatin assembly|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|cellular response to topologically incorrect protein|
|activation of MAPK activity|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|response to unfolded protein|
|intracellular receptor signaling pathway|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|hormone-mediated signaling pathway|
|response to temperature stimulus|
|DNA packaging|
|regulation of JNK cascade|
|response to topologically incorrect protein|
|cellular response to steroid hormone stimulus|
|cellular response to metal ion|
|regulation of protein ubiquitination|
|protein-DNA complex assembly|
|cellular response to toxic substance|
|cellular response to inorganic substance|
|regulation of protein modification by small protein conjugation or removal|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|transcription corepressor activity|
|protein-DNA complex subunit organization|
|positive regulation of MAP kinase activity|
|nuclear body|
|apoptotic signaling pathway|
|transcription coactivator activity|
|ubiquitin protein ligase binding|
|DNA conformation change|
|response to antibiotic|
|regulation of neuron death|
|response to steroid hormone|
|activation of protein kinase activity|
|transcription factor binding|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|enzyme binding|
|response to metal ion|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|cellular response to drug|
|protein kinase binding|
|protein heterodimerization activity|
|response to toxic substance|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|cellular response to hormone stimulus|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|positive regulation of cell death|
|chromatin organization|
|viral process|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|response to lipid|
|nucleolus|
|regulation of kinase activity|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|programmed cell death|
|positive regulation of phosphorylation|
|chromosome organization|
|response to nitrogen compound|
|cell death|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.26|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.22|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.95|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1037
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DAXX Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>