DBNL [The Human Chemical-Genetic Interaction Map Project]

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======= DBNL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DBNL
  * **<color #00a2e8>Official Name</color>**: drebrin like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28988|28988]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJU6|Q9UJU6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DBNL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DBNL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610106|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cofilin ADF|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|podosome assembly|
|site of polarized growth|
|ruffle assembly|
|postsynaptic actin cytoskeleton organization|
|postsynaptic cytoskeleton organization|
|positive regulation of dendritic spine morphogenesis|
|Rac protein signal transduction|
|ruffle organization|
|podosome|
|positive regulation of dendrite morphogenesis|
|activation of JUN kinase activity|
|positive regulation of dendritic spine development|
|positive regulation of axon extension|
|regulation of dendritic spine morphogenesis|
|enzyme activator activity|
|cortical actin cytoskeleton|
|clathrin-coated vesicle membrane|
|tertiary granule lumen|
|positive regulation of JUN kinase activity|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|actin filament|
|JNK cascade|
|positive regulation of axonogenesis|
|regulation of JUN kinase activity|
|postsynapse organization|
|regulation of dendrite morphogenesis|
|ruffle|
|synapse assembly|
|regulation of axon extension|
|regulation of postsynapse organization|
|stress-activated MAPK cascade|
|regulation of extent of cell growth|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|cell cortex|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|activation of MAPK activity|
|positive regulation of cell growth|
|regulation of actin filament polymerization|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of developmental growth|
|lamellipodium|
|regulation of cell size|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of axonogenesis|
|regulation of JNK cascade|
|protein C-terminus binding|
|postsynaptic membrane|
|actin filament binding|
|regulation of synapse organization|
|regulation of protein polymerization|
|regulation of synapse structure or activity|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|receptor-mediated endocytosis|
|protein domain specific binding|
|Ras protein signal transduction|
|postsynaptic density|
|early endosome|
|positive regulation of growth|
|regulation of actin filament organization|
|positive regulation of MAP kinase activity|
|actin binding|
|synapse organization|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|cadherin binding|
|small GTPase mediated signal transduction|
|activation of protein kinase activity|
|regulation of developmental growth|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|positive regulation of neuron differentiation|
|MAPK cascade|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|regulation of cell growth|
|dendrite|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|cell projection assembly|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|neutrophil degranulation|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|neutrophil activation involved in immune response|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|cell part morphogenesis|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|cell junction|
|endocytosis|
|actin filament-based process|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|adaptive immune response|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of growth|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulated exocytosis|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|organelle assembly|
|leukocyte mediated immunity|
|exocytosis|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of kinase activity|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|secretion by cell|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.73|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7671
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DBNL Expression in NALM6 Cells: 7.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>