DBR1 [The Human Chemical-Genetic Interaction Map Project]

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======= DBR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DBR1
  * **<color #00a2e8>Official Name</color>**: debranching RNA lariats 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51163|51163]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UK59|Q9UK59]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DBR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DBR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607024|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis. {ECO:0000269|PubMed:10982890, ECO:0000269|PubMed:16232320}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DBR1|
|Metallophos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA lariat debranching enzyme activity|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|RNA phosphodiester bond hydrolysis|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|nucleic acid phosphodiester bond hydrolysis|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.19|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.09|
|[[:results:exp539|42°C R08 exp539]]|-2.03|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.91|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.82|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.77|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.76|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.72|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.72|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.71|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.89|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.92|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.93|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bub3|BUB3]]|0.517|
|[[:human genes:m:mad1l1|MAD1L1]]|0.485|
|[[:human genes:m:med16|MED16]]|0.47|
|[[:human genes:m:mad2l1|MAD2L1]]|0.46|
|[[:human genes:r:rbm14|RBM14]]|0.446|
|[[:human genes:s:srp68|SRP68]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 737/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 40
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DBR1 Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>