DCAF5 [The Human Chemical-Genetic Interaction Map Project]

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======= DCAF5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCAF5
  * **<color #00a2e8>Official Name</color>**: DDB1 and CUL4 associated factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8816|8816]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JK2|Q96JK2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCAF5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCAF5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603812|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cul4-RING E3 ubiquitin ligase complex|
|post-translational protein modification|
|protein ubiquitination|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.47|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.24|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.77|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fbxo11|FBXO11]]|0.524|
|[[:human genes:t:thoc6|THOC6]]|0.463|
|[[:human genes:t:trim33|TRIM33]]|0.456|
|[[:human genes:m:med23|MED23]]|0.449|
|[[:human genes:i:id3|ID3]]|0.448|
|[[:human genes:m:med13l|MED13L]]|0.443|
|[[:human genes:u:ube3a|UBE3A]]|0.441|
|[[:human genes:d:dpf2|DPF2]]|0.437|
|[[:human genes:c:ccdc101|CCDC101]]|0.429|
|[[:human genes:a:alg5|ALG5]]|0.419|
|[[:human genes:t:taf5l|TAF5L]]|0.417|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.416|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.409|
|[[:human genes:a:atf7ip|ATF7IP]]|0.406|
|[[:human genes:c:cbx3|CBX3]]|0.402|
|[[:human genes:t:tceb3|TCEB3]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3627
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCAF5 Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>