DCLK2 [The Human Chemical-Genetic Interaction Map Project]

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======= DCLK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCLK2
  * **<color #00a2e8>Official Name</color>**: doublecortin like kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=166614|166614]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N568|Q8N568]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCLK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCLK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613166|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|DCX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pyramidal neuron development|
|pyramidal neuron differentiation|
|negative regulation of protein localization to nucleus|
|forebrain neuron development|
|forebrain neuron differentiation|
|forebrain generation of neurons|
|central nervous system neuron development|
|hippocampus development|
|limbic system development|
|negative regulation of cellular protein localization|
|regulation of protein localization to nucleus|
|pallium development|
|peptidyl-serine phosphorylation|
|central nervous system neuron differentiation|
|peptidyl-serine modification|
|telencephalon development|
|microtubule|
|protein serine/threonine kinase activity|
|forebrain development|
|microtubule cytoskeleton organization|
|regulation of cellular protein localization|
|microtubule-based process|
|brain development|
|head development|
|neuron development|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|protein phosphorylation|
|central nervous system development|
|neuron differentiation|
|regulation of protein localization|
|cytoskeleton organization|
|phosphorylation|
|ATP binding|
|generation of neurons|
|neurogenesis|
|cell development|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14690
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCLK2 Expression in NALM6 Cells: 0.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>