DCP2 [The Human Chemical-Genetic Interaction Map Project]

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======= DCP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCP2
  * **<color #00a2e8>Official Name</color>**: decapping mRNA 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=167227|167227]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IU60|Q8IU60]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609844|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:12218187, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:26098573}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DCP2|
|NUDIX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|exoribonuclease activity, producing 5-phosphomonoesters|
|5-3 exoribonuclease activity|
|deadenylation-dependent decapping of nuclear-transcribed mRNA|
|m7G(5)pppN diphosphatase activity|
|histone mRNA catabolic process|
|RISC complex|
|regulation of telomerase RNA localization to Cajal body|
|negative regulation of telomere maintenance via telomerase|
|telomerase RNA binding|
|negative regulation of telomere maintenance via telomere lengthening|
|histone mRNA metabolic process|
|exonucleolytic catabolism of deadenylated mRNA|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|regulation of telomere maintenance via telomerase|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of telomere maintenance via telomere lengthening|
|manganese ion binding|
|cytoplasmic ribonucleoprotein granule|
|regulation of telomere maintenance|
|P-body|
|regulation of DNA biosynthetic process|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|negative regulation of DNA metabolic process|
|negative regulation of chromosome organization|
|RNA phosphodiester bond hydrolysis|
|regulation of mRNA stability|
|regulation of RNA stability|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|regulation of mRNA metabolic process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|cell junction|
|mRNA metabolic process|
|negative regulation of cellular component organization|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|macromolecule catabolic process|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:edc3|EDC3]]|0.462|
|[[:human genes:d:ddx6|DDX6]]|0.457|
|[[:human genes:d:dctn6|DCTN6]]|0.422|
|[[:human genes:e:edc4|EDC4]]|0.42|
|[[:human genes:p:pmm2|PMM2]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2643
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCP2 Expression in NALM6 Cells: 7.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>