DCTN1 [The Human Chemical-Genetic Interaction Map Project]

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======= DCTN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCTN1
  * **<color #00a2e8>Official Name</color>**: dynactin subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1639|1639]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14203|Q14203]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCTN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCTN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601143|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAP GLY|
|Dynactin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of microtubule nucleation|
|positive regulation of neuromuscular junction development|
|regulation of microtubule nucleation|
|motor behavior|
|centriolar subdistal appendage|
|neuron projection maintenance|
|microtubule anchoring at centrosome|
|regulation of neuromuscular junction development|
|microtubule anchoring at microtubule organizing center|
|centriole-centriole cohesion|
|cell cortex region|
|maintenance of synapse structure|
|nuclear envelope disassembly|
|membrane disassembly|
|microtubule plus-end|
|retromer complex|
|dynein complex|
|microtubule anchoring|
|establishment of mitotic spindle orientation|
|positive regulation of microtubule polymerization|
|microtubule associated complex|
|establishment of mitotic spindle localization|
|neuron cellular homeostasis|
|positive regulation of microtubule polymerization or depolymerization|
|establishment of spindle orientation|
|regulation of mitotic spindle organization|
|neuron projection organization|
|neuromuscular junction development|
|regulation of spindle organization|
|establishment of spindle localization|
|non-motile cilium assembly|
|tau protein binding|
|motor activity|
|cellular component maintenance|
|intermediate filament cytoskeleton|
|ventral spinal cord development|
|spindle localization|
|regulation of microtubule polymerization|
|nuclear envelope organization|
|tubulin binding|
|IRE1-mediated unfolded protein response|
|axonal transport|
|axo-dendritic transport|
|regulation of microtubule polymerization or depolymerization|
|centrosome cycle|
|kinetochore|
|retrograde transport, endosome to Golgi|
|microtubule organizing center organization|
|ciliary basal body-plasma membrane docking|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|microtubule cytoskeleton organization involved in mitosis|
|endoplasmic reticulum unfolded protein response|
|spinal cord development|
|neuromuscular process|
|establishment of cell polarity|
|spindle|
|spindle pole|
|cellular response to unfolded protein|
|positive regulation of protein polymerization|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|nucleus organization|
|cell cortex|
|centriole|
|cytosolic transport|
|cellular response to topologically incorrect protein|
|transport along microtubule|
|response to unfolded protein|
|organelle localization by membrane tethering|
|cytoskeleton-dependent intracellular transport|
|antigen processing and presentation of exogenous peptide antigen|
|membrane docking|
|nuclear envelope|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|response to topologically incorrect protein|
|regulation of microtubule cytoskeleton organization|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|regulation of cell cycle G2/M phase transition|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|regulation of synapse organization|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|regulation of synapse structure or activity|
|endosomal transport|
|microtubule binding|
|positive regulation of protein complex assembly|
|response to endoplasmic reticulum stress|
|mitotic cell cycle phase transition|
|synapse organization|
|microtubule-based movement|
|cell cycle phase transition|
|axon|
|microtubule|
|neuron projection|
|anatomical structure homeostasis|
|cilium assembly|
|regulation of supramolecular fiber organization|
|establishment of organelle localization|
|cilium organization|
|neuronal cell body|
|Golgi vesicle transport|
|cellular component disassembly|
|regulation of mitotic cell cycle phase transition|
|endomembrane system organization|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|cell projection assembly|
|protein kinase binding|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|behavior|
|organelle localization|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|membrane organization|
|cellular homeostasis|
|regulation of cellular component biogenesis|
|central nervous system development|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|nervous system process|
|intracellular transport|
|movement of cell or subcellular component|
|homeostatic process|
|cellular response to stress|
|establishment of localization in cell|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.7|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1500
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCTN1 Expression in NALM6 Cells: 7.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>