DCTN5 [The Human Chemical-Genetic Interaction Map Project]

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======= DCTN5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCTN5
  * **<color #00a2e8>Official Name</color>**: dynactin subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84516|84516]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BTE1|Q9BTE1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCTN5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCTN5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612962|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hexapep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|coronary vasculature development|
|aorta development|
|ventricular septum development|
|artery development|
|condensed chromosome kinetochore|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|cardiac septum development|
|cardiac ventricle development|
|cardiac chamber development|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|nuclear membrane|
|Golgi vesicle transport|
|blood vessel development|
|centrosome|
|vasculature development|
|cardiovascular system development|
|heart development|
|circulatory system development|
|intracellular transport|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.13|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-2.02|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.85|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.73|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.444|
|[[:human genes:r:rtcb|RTCB]]|0.433|
|[[:human genes:d:dctn6|DCTN6]]|0.42|
|[[:human genes:r:rnmt|RNMT]]|0.42|
|[[:human genes:h:haus8|HAUS8]]|0.419|
|[[:human genes:g:gnb1l|GNB1L]]|0.418|
|[[:human genes:d:ddx20|DDX20]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 684/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|26/28|
|bone|25/26|
|breast|28/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|19/21|
|liver|20/20|
|lung|70/75|
|lymphocyte|16/16|
|ovary|23/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 268
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCTN5 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>