DDIT4 [The Human Chemical-Genetic Interaction Map Project]

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======= DDIT4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDIT4
  * **<color #00a2e8>Official Name</color>**: DNA damage inducible transcript 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54541|54541]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX09|Q9NX09]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDIT4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDIT4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607729|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. {ECO:0000250, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201, ECO:0000269|PubMed:15988001, ECO:0000269|PubMed:17005863, ECO:0000269|PubMed:17379067, ECO:0000269|PubMed:19557001, ECO:0000269|PubMed:20166753, ECO:0000269|PubMed:21460850}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RTP801 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of glycolytic process|
|negative regulation of peptidyl-threonine phosphorylation|
|negative regulation of purine nucleotide metabolic process|
|negative regulation of nucleotide metabolic process|
|neurotrophin TRK receptor signaling pathway|
|negative regulation of ATP metabolic process|
|negative regulation of peptidyl-serine phosphorylation|
|neurotrophin signaling pathway|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|14-3-3 protein binding|
|cellular response to dexamethasone stimulus|
|response to dexamethasone|
|negative regulation of cellular carbohydrate metabolic process|
|regulation of peptidyl-threonine phosphorylation|
|negative regulation of carbohydrate metabolic process|
|negative regulation of TOR signaling|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of glycolytic process|
|intracellular|
|regulation of carbohydrate catabolic process|
|negative regulation of small molecule metabolic process|
|cellular response to ketone|
|positive regulation of neuron death|
|response to antineoplastic agent|
|regulation of TOR signaling|
|reactive oxygen species metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|neuron migration|
|signal transduction by p53 class mediator|
|regulation of ATP metabolic process|
|regulation of peptidyl-serine phosphorylation|
|regulation of cellular carbohydrate metabolic process|
|response to glucocorticoid|
|intrinsic apoptotic signaling pathway|
|regulation of generation of precursor metabolites and energy|
|response to corticosteroid|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|defense response to virus|
|response to ketone|
|regulation of carbohydrate metabolic process|
|protein-containing complex disassembly|
|response to virus|
|apoptotic signaling pathway|
|response to xenobiotic stimulus|
|negative regulation of catabolic process|
|regulation of neuron death|
|response to steroid hormone|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|cellular component disassembly|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|regulation of small molecule metabolic process|
|negative regulation of phosphorylation|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular response to lipid|
|response to growth factor|
|cellular response to organic cyclic compound|
|cell population proliferation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|brain development|
|cellular response to DNA damage stimulus|
|head development|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|defense response to other organism|
|cell migration|
|central nervous system development|
|regulation of catabolic process|
|neuron differentiation|
|response to drug|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|cell death|
|immune effector process|
|negative regulation of protein metabolic process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|mitochondrion|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.75|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17947
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDIT4 Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>