DDTL [The Human Chemical-Genetic Interaction Map Project]

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======= DDTL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDTL
  * **<color #00a2e8>Official Name</color>**: D-dopachrome tautomerase like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100037417|100037417]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6NHG4|A6NHG4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDTL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDTL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May have lyase activity. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lyase activity|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.96|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.91|
|[[:results:exp539|42°C R08 exp539]]|-1.89|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.82|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.84|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.86|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.98|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.618|
|[[:human genes:p:psmd11|PSMD11]]|0.609|
|[[:human genes:p:psma6|PSMA6]]|0.597|
|[[:human genes:c:chd4|CHD4]]|0.584|
|[[:human genes:r:rps12|RPS12]]|0.58|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.57|
|[[:human genes:t:tceb3c|TCEB3C]]|0.568|
|[[:human genes:p:psmd1|PSMD1]]|0.567|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.566|
|[[:human genes:k:kctd17|KCTD17]]|0.558|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.556|
|[[:human genes:h:hivep3|HIVEP3]]|0.543|
|[[:human genes:c:cbwd3|CBWD3]]|0.542|
|[[:human genes:l:lrr1|LRR1]]|0.541|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.541|
|[[:human genes:z:zfand5|ZFAND5]]|0.539|
|[[:human genes:s:slc6a17|SLC6A17]]|0.53|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.528|
|[[:human genes:s:ssh2|SSH2]]|0.522|
|[[:human genes:m:mt1e|MT1E]]|0.521|
|[[:human genes:n:nupl1|NUPL1]]|0.519|
|[[:human genes:p:psma7|PSMA7]]|0.518|
|[[:human genes:t:tfip11|TFIP11]]|0.516|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.514|
|[[:human genes:c:copg1|COPG1]]|0.514|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.514|
|[[:human genes:a:aaas|AAAS]]|0.513|
|[[:human genes:t:top1mt|TOP1MT]]|0.512|
|[[:human genes:v:vasn|VASN]]|0.512|
|[[:human genes:c:cbwd5|CBWD5]]|0.511|
|[[:human genes:l:lad1|LAD1]]|0.51|
|[[:human genes:r:rnpc3|RNPC3]]|0.509|
|[[:human genes:c:ctage4|CTAGE4]]|0.509|
|[[:human genes:s:syt9|SYT9]]|0.508|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.507|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.506|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.506|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.505|
|[[:human genes:p:psmb4|PSMB4]]|0.504|
|[[:human genes:d:dtl|DTL]]|0.504|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.503|
|[[:human genes:r:rpl35|RPL35]]|0.502|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.502|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.501|
|[[:human genes:s:slc4a1|SLC4A1]]|0.5|
|[[:human genes:c:cactin|CACTIN]]|0.498|
|[[:human genes:p:pcf11|PCF11]]|0.498|
|[[:human genes:p:psmd2|PSMD2]]|0.496|
|[[:human genes:h:hap1|HAP1]]|0.494|
|[[:human genes:i:ints5|INTS5]]|0.494|
|[[:human genes:g:golga8o|GOLGA8O]]|0.494|
|[[:human genes:t:twistnb|TWISTNB]]|0.492|
|[[:human genes:c:copa|COPA]]|0.492|
|[[:human genes:a:atxn1|ATXN1]]|0.492|
|[[:human genes:d:disp2|DISP2]]|0.492|
|[[:human genes:c:cdca3|CDCA3]]|0.491|
|[[:human genes:p:psmd14|PSMD14]]|0.491|
|[[:human genes:p:psmc2|PSMC2]]|0.491|
|[[:human genes:r:rbm39|RBM39]]|0.491|
|[[:human genes:p:psmd3|PSMD3]]|0.49|
|[[:human genes:f:fam160a1|FAM160A1]]|0.489|
|[[:human genes:r:rbbp5|RBBP5]]|0.488|
|[[:human genes:m:madcam1|MADCAM1]]|0.487|
|[[:human genes:n:nop16|NOP16]]|0.487|
|[[:human genes:a:atp13a1|ATP13A1]]|0.486|
|[[:human genes:c:cbwd6|CBWD6]]|0.486|
|[[:human genes:u:upf1|UPF1]]|0.485|
|[[:human genes:s:slc38a7|SLC38A7]]|0.484|
|[[:human genes:m:myh7b|MYH7B]]|0.484|
|[[:human genes:o:orc1|ORC1]]|0.483|
|[[:human genes:c:c14orf93|C14orf93]]|0.483|
|[[:human genes:z:znf541|ZNF541]]|0.483|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.482|
|[[:human genes:s:sec13|SEC13]]|0.482|
|[[:human genes:s:slc5a5|SLC5A5]]|0.48|
|[[:human genes:c:cope|COPE]]|0.479|
|[[:human genes:a:ankle1|ANKLE1]]|0.479|
|[[:human genes:s:sel1l|SEL1L]]|0.479|
|[[:human genes:s:smg7|SMG7]]|0.479|
|[[:human genes:r:rpl34|RPL34]]|0.479|
|[[:human genes:a:akap1|AKAP1]]|0.478|
|[[:human genes:f:fcn2|FCN2]]|0.478|
|[[:human genes:d:dhx38|DHX38]]|0.478|
|[[:human genes:n:nol8|NOL8]]|0.478|
|[[:human genes:n:narfl|NARFL]]|0.477|
|[[:human genes:s:supt6h|SUPT6H]]|0.477|
|[[:human genes:r:rps2|RPS2]]|0.477|
|[[:human genes:a:ankle2|ANKLE2]]|0.475|
|[[:human genes:a:acsf2|ACSF2]]|0.475|
|[[:human genes:t:ticrr|TICRR]]|0.475|
|[[:human genes:n:nup54|NUP54]]|0.475|
|[[:human genes:a:akirin2|AKIRIN2]]|0.473|
|[[:human genes:i:ik|IK]]|0.473|
|[[:human genes:c:cdc73|CDC73]]|0.473|
|[[:human genes:r:rfc1|RFC1]]|0.473|
|[[:human genes:p:pola1|POLA1]]|0.472|
|[[:human genes:r:rrp15|RRP15]]|0.471|
|[[:human genes:p:psmc1|PSMC1]]|0.471|
|[[:human genes:o:or10g3|OR10G3]]|0.471|
|[[:human genes:x:xab2|XAB2]]|0.471|
|[[:human genes:s:s1pr4|S1PR4]]|0.47|
|[[:human genes:c:ccna2|CCNA2]]|0.469|
|[[:human genes:n:nbpf10|NBPF10]]|0.468|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.468|
|[[:human genes:p:paf1|PAF1]]|0.467|
|[[:human genes:r:rad21|RAD21]]|0.465|
|[[:human genes:m:mcoln1|MCOLN1]]|0.464|
|[[:human genes:r:rrn3|RRN3]]|0.464|
|[[:human genes:p:pan3|PAN3]]|0.463|
|[[:human genes:p:pan2|PAN2]]|0.463|
|[[:human genes:a:aqr|AQR]]|0.463|
|[[:human genes:h:hist2h3d|HIST2H3D]]|0.462|
|[[:human genes:s:smg1|SMG1]]|0.462|
|[[:human genes:c:ctr9|CTR9]]|0.459|
|[[:human genes:z:znf830|ZNF830]]|0.459|
|[[:human genes:p:pola2|POLA2]]|0.458|
|[[:human genes:n:npipb5|NPIPB5]]|0.458|
|[[:human genes:p:psmb1|PSMB1]]|0.458|
|[[:human genes:c:cdt1|CDT1]]|0.456|
|[[:human genes:p:pwp2|PWP2]]|0.456|
|[[:human genes:w:wdr43|WDR43]]|0.456|
|[[:human genes:u:uqcrh|UQCRH]]|0.455|
|[[:human genes:c:cdc45|CDC45]]|0.454|
|[[:human genes:s:sf3a1|SF3A1]]|0.454|
|[[:human genes:r:rps19|RPS19]]|0.453|
|[[:human genes:w:wdr87|WDR87]]|0.452|
|[[:human genes:g:golga8j|GOLGA8J]]|0.452|
|[[:human genes:i:igfn1|IGFN1]]|0.452|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.452|
|[[:human genes:r:rps28|RPS28]]|0.452|
|[[:human genes:d:dnm2|DNM2]]|0.452|
|[[:human genes:p:psmb2|PSMB2]]|0.451|
|[[:human genes:n:nbpf16|NBPF16]]|0.451|
|[[:human genes:b:bysl|BYSL]]|0.451|
|[[:human genes:r:rfpl3|RFPL3]]|0.45|
|[[:human genes:f:fam25b|FAM25B]]|0.45|
|[[:human genes:d:dock6|DOCK6]]|0.45|
|[[:human genes:w:wdr75|WDR75]]|0.45|
|[[:human genes:u:utp3|UTP3]]|0.45|
|[[:human genes:c:copb1|COPB1]]|0.449|
|[[:human genes:r:rrp7a|RRP7A]]|0.448|
|[[:human genes:r:ranbp2|RANBP2]]|0.448|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.448|
|[[:human genes:s:snrpa1|SNRPA1]]|0.448|
|[[:human genes:r:rps9|RPS9]]|0.448|
|[[:human genes:m:myt1l|MYT1L]]|0.447|
|[[:human genes:d:ddx56|DDX56]]|0.447|
|[[:human genes:k:kif3c|KIF3C]]|0.447|
|[[:human genes:c:chmp2a|CHMP2A]]|0.447|
|[[:human genes:p:psmd7|PSMD7]]|0.446|
|[[:human genes:o:orc6|ORC6]]|0.446|
|[[:human genes:r:rnf113a|RNF113A]]|0.446|
|[[:human genes:a:aamp|AAMP]]|0.444|
|[[:human genes:m:myo1h|MYO1H]]|0.444|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.444|
|[[:human genes:p:psmd13|PSMD13]]|0.443|
|[[:human genes:z:znf106|ZNF106]]|0.443|
|[[:human genes:n:nup205|NUP205]]|0.443|
|[[:human genes:i:iscu|ISCU]]|0.443|
|[[:human genes:r:rfxank|RFXANK]]|0.443|
|[[:human genes:p:polr2d|POLR2D]]|0.442|
|[[:human genes:c:casc3|CASC3]]|0.442|
|[[:human genes:p:psmc6|PSMC6]]|0.441|
|[[:human genes:p:pbxip1|PBXIP1]]|0.441|
|[[:human genes:p:polr2f|POLR2F]]|0.441|
|[[:human genes:r:rpsa|RPSA]]|0.44|
|[[:human genes:p:pole|POLE]]|0.439|
|[[:human genes:m:med17|MED17]]|0.439|
|[[:human genes:a:aatf|AATF]]|0.438|
|[[:human genes:t:topbp1|TOPBP1]]|0.438|
|[[:human genes:s:supt5h|SUPT5H]]|0.438|
|[[:human genes:u:utp18|UTP18]]|0.438|
|[[:human genes:p:psmb3|PSMB3]]|0.437|
|[[:human genes:r:rpl6|RPL6]]|0.437|
|[[:human genes:s:sult1a3|SULT1A3]]|0.436|
|[[:human genes:c:ccdc116|CCDC116]]|0.436|
|[[:human genes:x:xylt2|XYLT2]]|0.436|
|[[:human genes:e:esf1|ESF1]]|0.435|
|[[:human genes:p:ppfia4|PPFIA4]]|0.435|
|[[:human genes:s:sult1a4|SULT1A4]]|0.435|
|[[:human genes:s:snip1|SNIP1]]|0.434|
|[[:human genes:o:ogfr|OGFR]]|0.434|
|[[:human genes:a:ahctf1|AHCTF1]]|0.433|
|[[:human genes:t:traip|TRAIP]]|0.433|
|[[:human genes:a:arcn1|ARCN1]]|0.431|
|[[:human genes:c:col2a1|COL2A1]]|0.431|
|[[:human genes:h:haus4|HAUS4]]|0.431|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.429|
|[[:human genes:s:stil|STIL]]|0.428|
|[[:human genes:n:nfatc4|NFATC4]]|0.428|
|[[:human genes:s:sf3a3|SF3A3]]|0.427|
|[[:human genes:l:lrrc56|LRRC56]]|0.426|
|[[:human genes:s:sap30bp|SAP30BP]]|0.426|
|[[:human genes:c:cln6|CLN6]]|0.426|
|[[:human genes:k:kpnb1|KPNB1]]|0.425|
|[[:human genes:c:cmya5|CMYA5]]|0.425|
|[[:human genes:p:plk4|PLK4]]|0.424|
|[[:human genes:n:nup153|NUP153]]|0.424|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.424|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.424|
|[[:human genes:s:srrt|SRRT]]|0.423|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.422|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.422|
|[[:human genes:p:pdcd11|PDCD11]]|0.422|
|[[:human genes:e:exosc3|EXOSC3]]|0.422|
|[[:human genes:e:exosc9|EXOSC9]]|0.421|
|[[:human genes:s:scaf1|SCAF1]]|0.421|
|[[:human genes:c:chaf1a|CHAF1A]]|0.421|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.42|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.42|
|[[:human genes:e:exosc6|EXOSC6]]|0.42|
|[[:human genes:p:psmd6|PSMD6]]|0.42|
|[[:human genes:n:nol12|NOL12]]|0.42|
|[[:human genes:r:rpl30|RPL30]]|0.419|
|[[:human genes:n:nup160|NUP160]]|0.418|
|[[:human genes:g:gar1|GAR1]]|0.418|
|[[:human genes:m:map7d1|MAP7D1]]|0.417|
|[[:human genes:z:znf655|ZNF655]]|0.416|
|[[:human genes:m:mfsd12|MFSD12]]|0.416|
|[[:human genes:m:myb|MYB]]|0.416|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.416|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.416|
|[[:human genes:r:rilpl2|RILPL2]]|0.415|
|[[:human genes:s:smc2|SMC2]]|0.415|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.415|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.415|
|[[:human genes:p:plk1|PLK1]]|0.414|
|[[:human genes:c:ccdc94|CCDC94]]|0.414|
|[[:human genes:s:sfpq|SFPQ]]|0.414|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.413|
|[[:human genes:m:med14|MED14]]|0.413|
|[[:human genes:n:nkd2|NKD2]]|0.413|
|[[:human genes:b:brix1|BRIX1]]|0.412|
|[[:human genes:t:tspy8|TSPY8]]|0.412|
|[[:human genes:c:ctage9|CTAGE9]]|0.412|
|[[:human genes:e:eif4a3|EIF4A3]]|0.411|
|[[:human genes:k:krt2|KRT2]]|0.411|
|[[:human genes:n:nup43|NUP43]]|0.41|
|[[:human genes:g:gid4|GID4]]|0.41|
|[[:human genes:v:vps54|VPS54]]|0.41|
|[[:human genes:m:myh2|MYH2]]|0.41|
|[[:human genes:m:mat2a|MAT2A]]|0.409|
|[[:human genes:n:napa|NAPA]]|0.409|
|[[:human genes:n:nup107|NUP107]]|0.409|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.408|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.408|
|[[:human genes:l:loc643669|LOC643669]]|0.408|
|[[:human genes:c:ckap5|CKAP5]]|0.408|
|[[:human genes:n:nsf|NSF]]|0.408|
|[[:human genes:t:tsg101|TSG101]]|0.407|
|[[:human genes:h:hinfp|HINFP]]|0.406|
|[[:human genes:g:gprin2|GPRIN2]]|0.406|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.406|
|[[:human genes:c:cep192|CEP192]]|0.406|
|[[:human genes:v:vps28|VPS28]]|0.406|
|[[:human genes:p:pop1|POP1]]|0.405|
|[[:human genes:a:apc2|APC2]]|0.405|
|[[:human genes:s:smg5|SMG5]]|0.404|
|[[:human genes:p:polr1a|POLR1A]]|0.404|
|[[:human genes:r:rad51|RAD51]]|0.404|
|[[:human genes:s:specc1l|SPECC1L]]|0.404|
|[[:human genes:t:ttyh1|TTYH1]]|0.403|
|[[:human genes:f:foxd4l2|FOXD4L2]]|0.403|
|[[:human genes:e:egr2|EGR2]]|0.402|
|[[:human genes:d:dhfr|DHFR]]|0.402|
|[[:human genes:t:tuba8|TUBA8]]|0.402|
|[[:human genes:c:cwc22|CWC22]]|0.402|
|[[:human genes:n:nol10|NOL10]]|0.402|
|[[:human genes:v:vps52|VPS52]]|0.401|
|[[:human genes:c:chmp4b|CHMP4B]]|0.4|
|[[:human genes:r:rrp1|RRP1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1687
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDTL Expression in NALM6 Cells: 3.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>