DDX18 [The Human Chemical-Genetic Interaction Map Project]

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======= DDX18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX18
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8886|8886]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVP1|Q9NVP1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606355|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable RNA-dependent helicase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of LSU-rRNA|
|cellular response to estradiol stimulus|
|RNA helicase activity|
|ribosomal large subunit biogenesis|
|chromosome|
|response to estradiol|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|response to lipid|
|nucleolus|
|RNA processing|
|response to hormone|
|response to organic cyclic compound|
|cellular response to oxygen-containing compound|
|cellular response to endogenous stimulus|
|RNA binding|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.11|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.96|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.78|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.73|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.71|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.71|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.74|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.82|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.03|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.08|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.12|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.2|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.427|
|[[:human genes:r:rrp7a|RRP7A]]|0.411|
|[[:human genes:p:polr2j3|POLR2J3]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 292/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|5/28|
|bone|6/26|
|breast|16/33|
|central nervous system|25/56|
|cervix|2/4|
|colorectal|8/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|9/21|
|liver|5/20|
|lung|29/75|
|lymphocyte|5/16|
|ovary|7/26|
|pancreas|5/24|
|peripheral nervous system|4/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|10/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|8/22|
|urinary tract|16/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1014
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX18 Expression in NALM6 Cells: 7.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>